| Author | Chung, Andrew W. | |
| Author | Sieling, Peter A. | |
| Author | Schenk, Mirjam | |
| Author | Teles, Rosane M. B. | |
| Author | Krutzik, Stephan R. | |
| Author | Hsu, Daniel K. | |
| Author | Liu, Fu-Tong | |
| Author | Sarno, Euzenir N. | |
| Author | Rea, Thomas H. | |
| Author | Stenger, Steffen | |
| Author | Modlin, Robert L. | |
| Author | Lee, Delphine J. | |
| Access date | 2015-09-21T17:25:35Z | |
| Available date | 2015-09-21T17:25:35Z | |
| Document date | 2013 | |
| Citation | CHUNG, Andrew W.; et al. Galectin-3 Regulates the Innate Immune Response of Human Monocytes. J. Infect Dis., v.207, n.6, p.947-956, 2013. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| ISSN | 1537-6613 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11742 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | |
| Title | Galectin-3 Regulates the Innate Immune Response of Human Monocytes | pt_BR |
| Type | Article | |
| DOI | 10.1093/infdis/jis920 | pt_BR |
| Abstract | Galectin-3 is a β-galactoside–binding lectin widely expressed on epithelial and hematopoietic cells, and its expression
is frequently associated with a poor prognosis in cancer. Because it has not been well-studied in human
infectious disease, we examined galectin-3 expression in mycobacterial infection by studying leprosy, an intracellular
infection caused by Mycobacterium leprae. Galectin-3 was highly expressed on macrophages in lesions of
patients with the clinically progressive lepromatous form of leprosy; in contrast, galectin-3 was almost undetectable
in self-limited tuberculoid lesions. We investigated the potential function of galectin-3 in cell-mediated
immunity using peripheral blood monocytes. Galectin-3 enhanced monocyte interleukin 10 production to a
TLR2/1 ligand, whereas interleukin 12p40 secretion was unaffected. Furthermore, galectin-3 diminished monocyte
to dendritic cell differentiation and T-cell antigen presentation. These data demonstrate an association of galectin-
3 with unfavorable host response in leprosy and a potential mechanism for impaired host defense in humans. | pt_BR |
| Affilliation | John Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA. | pt_BR |
| Affilliation | John Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA. | pt_BR |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA. | pt_BR |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA. | pt_BR |
| Affilliation | University of California. Davis School of Medicine. Department of Dermatology. Sacramento, USA / Academia Sinica. Institute of BioMedical Sciences. Taipei, Taiwan, Republic of China. | pt_BR |
| Affilliation | University of California. Davis School of Medicine. Department of Dermatology. Sacramento, USA / Academia Sinica. Institute of BioMedical Sciences. Taipei, Taiwan, Republic of China. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Southern California. School of Medicine. Department of Dermatology. Los Angeles, USA. | pt_BR |
| Affilliation | University Hospital of Ulm. Institute for Medical Microbiology and Hygiene. Germany. | pt_BR |
| Affilliation | University of California. David Geffen School of Medicine. Department of Medicine. Division of Dermatology. Los Angeles, USA / University of California. David Geffen School of Medicine. Department of Microbiology, Immunology, and Molecular Genetics. Los Angeles, USA. | pt_BR |
| Affilliation | John Wayne Cancer Institute at Saint John’s Health Center. Department of Translational Immunology. 1Dirks/Dougherty Laboratory for Cancer Research. Santa Monica, CA, USA. | pt_BR |
| Subject | Human | pt_BR |
| Subject | Bacterial infection | pt_BR |
| Subject | Galectin-3 | pt_BR |
| Subject | Monocytes/macrophages; | pt_BR |
| Subject | TLR2 | pt_BR |
| DeCS | nfecções Bacterianas | pt_BR |
| DeCS | Monócitos | pt_BR |
| DeCS | Macrófagos | pt_BR |
| DeCS | Humanos | pt_BR |
