| Author | Santos, Daiane Santos dos | |
| Author | Duppre, Nádia Cristina | |
| Author | Sales, Ana Maria | |
| Author | Nery, José Augusto da Costa | |
| Author | Sarno, Euzenir Nunes | |
| Author | Hacker, Mariana Andréa | |
| Access date | 2015-09-21T17:25:36Z | |
| Available date | 2015-09-21T17:25:36Z | |
| Document date | 2013 | |
| Citation | SANTOS, Daiane Santos dos; et al. Kinship and Leprosy in the Contacts of Leprosy Patients: Cohort at the Souza Araújo Outpatient Clinic, Rio de Janeiro, RJ, 1987–2010. Journal of Tropical Medicine, v. 2013, Article ID596316, 8p, 2013. | pt_BR |
| ISSN | 1687-9694 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11744 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Contatos | pt_BR |
| Subject in Portuguese | Parentesco | pt_BR |
| Subject in Portuguese | Pacientes | pt_BR |
| Title | Kinship and Leprosy in the Contacts of Leprosy Patients: Cohort at the Souza Araújo Outpatient Clinic, Rio de Janeiro, RJ, 1987–2010 | pt_BR |
| Type | Article | |
| DOI | 10.1155/2013/596316 | pt_BR |
| Abstract | A broad variety of factors have been associated with leprosy among contacts, including socioeconomic, epidemiological, and
genetic characteristics. Data from 7,174 contacts of leprosy patients from a leprosy outpatient clinic in Rio de Janeiro, Brazil, 1987–
2010, were analyzed to investigate the effects of kinship, individual, and contextual factors on leprosy. Multivariate analyses were
performed using a robust estimation method. In the prevalence analysis, close kinship (sibling OR = 2.75, offspring OR = 2.00, and
other relatives OR = 1.70), socioeconomic factors, and the duration of exposure to the bacillus were associated to leprosy. In the
incidence analysis, significant risks were found for all categories of kinship (parents RR = 10.93, spouse, boyfriend/girlfriend, and
bride/groomRR = 7.53, sibling RR = 7.03, offspring RR = 5.34, and other relatives RR = 3.71). Once the treatment of the index case was
initiated, other factors lost their significance, and the index case bacteriological index and BCG (Bacillus Calmette-Gu´erin vaccine)
protection had a greater impact. Our findings suggested that both genetic susceptibility and physical exposure play an important
role in the epidemiology of leprosy, but it was not possible establishing the role of genetic factor. Analyses of other factors related
to the genotype of individuals, such as genetic polymorphisms, are needed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leprosy | pt_BR |
| Subject | Souza AraújoOutpatient Clinic | pt_BR |
| Subject | Patients | pt_BR |
| Subject | Kinship | pt_BR |
| Subject | Contacts | pt_BR |
| DeCS | Hanseníase | pt_BR |
