| Author | Gomes, Tatiana Luna | |
| Author | Bozza, Patrícia T. | |
| Author | Melo, Christiane Bandeira | |
| Access date | 2015-09-21T17:25:40Z | |
| Available date | 2015-09-21T17:25:40Z | |
| Document date | 2013 | |
| Citation | GOMES, Tatiana Luna; BOZZA, Patrícia T.; MELO, Christiane Bandeira. Eosinophil recruitment and activation: the role of lipid mediators. Front. Pharmacol., v.4, n.27, Mar. 2013. | pt_BR |
| ISSN | 1663-4365 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11758 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media S.A. | pt_BR |
| Rights | open access | |
| Title | Eosinophil recruitment and activation: the role of lipid mediators | pt_BR |
| Type | Article | |
| DOI | 10.3389/fphar.2013.00027 | pt_BR |
| Abstract | Eosinophils are effector cells that migrate toward several mediators released at inflammatory sites to perform their multiple functions. The mechanisms driving eosinophil selective accumulation in sites of allergic inflammation are well-established and involve several steps controlled by adhesion molecules, priming agents, chemotactic, and surviving factors. Even though the majority of studies focused on role of protein mediators like IL-5 and eotaxins, lipid mediators also participate in eosinophil recruitment and activation. Among the lipid mediators with distinguish eosinophil recruitment and activation capabilities are platelet activating factor and the eicosanoids, including leukotriene B4, cysteinyl leukotrienes, and prostaglandin D2. In this review, we focused on the role of these four lipid mediators in eosinophil recruitment and activation, since they are recognized as key mediators of eosinophilic inflammatory responses. | pt_BR |
| Affilliation | Universidade Federal do Rio deJaneiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio deJaneiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Eosinophil | pt_BR |
| Subject | Chemotaxis | pt_BR |
| Subject | Lipid mediators | pt_BR |
| Subject | Prostaglandins | pt_BR |
| Subject | Prostaglandinas | pt_BR |
| DeCS | Eosinófilo | pt_BR |
| DeCS | Prostaglandinas | pt_BR |
| DeCS | Leukotrienes | pt_BR |
