| Author | Alvardo-Mora, Mónica V. | |
| Author | Lima, Livia S. Botelho | |
| Author | Santana, Rubia A. | |
| Author | Sitnik, Roberta | |
| Author | Ferreira, Paulo Abrão | |
| Author | Mello, Francisco do Amaral | |
| Author | Mangueira, Cristovão P. | |
| Author | Carrilho, Flair J. | |
| Author | Pinho, João R. Rebello | |
| Access date | 2015-09-21T17:25:43Z | |
| Available date | 2015-09-21T17:25:43Z | |
| Document date | 2013 | |
| Citation | ALVARADO-MORA, Mónica V.; Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil. BMC Research Notes, v.6, n.423, 5p, 2013. | pt_BR |
| ISSN | 1756-0500 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11767 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1186/1756-0500-6-423 | pt_BR |
| Abstract | Background: HBV genotype F is primarily found in indigenous populations from South America and is classified in
four subgenotypes (F1 to F4). Subgenotype F2a is the most common in Brazil among genotype F cases. The aim of
this study was to characterize HBV genotype F2a circulating in 16 patients from São Paulo, Brazil. Samples were
collected between 2006 and 2012 and sent to Hospital Israelita Albert Einstein. A fragment of 1306 bp partially
comprising HBsAg and DNA polymerase coding regions was amplified and sequenced. Viral sequences were
genotyped by phylogenetic analysis using reference sequences from GenBank (n=198), including 80 classified as
subgenotype F2a. Bayesian Markov chain Monte Carlo simulation implemented in BEAST v.1.5.4 was applied to
obtain the best possible estimates using the model of nucleotide substitutions GTR+G+I.
Findings: It were identified three groups of sequences of subgenotype F2a: 1) 10 sequences from São Paulo state;
2) 3 sequences from Rio de Janeiro and one from São Paulo states; 3) 8 sequences from the West Amazon Basin.
Conclusions: These results showing for the first time the distribution of F2a subgenotype in Brazil. The spreading
and the dynamic of subgenotype F2a in Brazil requires the study of a higher number of samples from different
regions as it is unfold in almost all Brazilian populations studied so far. We cannot infer with certainty the origin of
these different groups due to the lack of available sequences. Nevertheless, our data suggest that the common
origin of these groups probably occurred a long time ago. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. UNIFESP. São Paulo, SP, Braisl. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil / Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil / Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil. | pt_BR |
| Subject | Hepatitis B | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Bayesian analysis | pt_BR |
| DeCS | Hepatite B | pt_BR |
| DeCS | Teorema de Bayes | pt_BR |
