| Author | Souza, Thiago Moreno L | |
| Author | Resende, Paola C. | |
| Author | Rodrigues, Natalia Fintelman | |
| Author | Gregianini, Tatiana Schaffer | |
| Author | Ikuta, Nilo | |
| Author | Fernandes, Sandra Bianchini | |
| Author | Cury, Ana Luisa Furtado | |
| Author | Rosa, Maria do Carmo Debur | |
| Author | Siqueira, Marilda Agudo Mendonça Teixeira de | |
| Access date | 2015-09-21T17:25:44Z | |
| Available date | 2015-09-21T17:25:44Z | |
| Document date | 2013 | |
| Citation | SOUZA, Thiago Moreno L.; et al. Detection of Oseltamivir-Resistant Pandemic Influenza A(H1N1)pdm2009 in Brazil: Can Community Transmission Be Ruled Out?. PLoS One, v.8, n.11, e80081, 6p, Nov. 2013. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11771 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | |
| Title | Detection of Oseltamivir-Resistant Pandemic Influenza A(H1N1)pdm2009 in Brazil: Can Community Transmission Be Ruled Out? | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0080081 | pt_BR |
| Abstract | Although surveillance efforts that monitor the emergence of drug-resistant strains of influenza are critical, systematic
analysis is overlooked in most developing countries. We report on the occurrence of strains of pandemic influenza
A(H1N1)pdm09 with resistance and decreased susceptibility to oseltamivir (OST) in Brazil in 2009, 2011 and 2012.
We found 7 mutant viruses, 2 with the mutation S247N and other 5 with the mutation H275Y. Most of these viruses
were from samples concentrated in the southern region of Brazil. Some of these resistant viruses were detected prior
to the initiation of OST treatment, suggesting that community transmission of mutant viruses may exist. Moreover, we
show that one of these OST-resistant (H275Y) strains of A(H1N1)pdm09 was discovered in the tri-border region
between Brazil, Argentina and Paraguay, highlighting that this strain could also be found in other Latin American
countries. Our findings reinforce the importance of enhanced antiviral resistance surveillance in Brazil and in other
Latin American countries to confirm or rule out the community transmission of OST-resistant strains of
A(H1N1)pdm09. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde. Laboratório Central de Saúde Pública do Estado do Rio de Grande do Sul. Seção de Virologia. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Luterana do Brasil. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Laboratório Central de Saúde Pública do Estado de Santa Catarina. Florianópolis, SC, Brasil. | pt_BR |
| Affilliation | Fundação Ezequiel Dias. Instituto Octávio Magalhães. Laboratório Central de Saúde Pública do Estado de Minas Gerais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Laboratório Central de Saúde Pública do Estado do Paraná. Curitiba, PR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Oseltamivir | pt_BR |
| Subject | Pandemic Influenza | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Drug-resistant | pt_BR |
| Subject | Influenza A(H1N1)pdm2009 | pt_BR |
| DeCS | Oseltamivir | pt_BR |
| DeCS | Influenza Pandêmica | pt_BR |
| DeCS | Resistência a Medicamentos | pt_BR |
