| Author | Estato, Vanessa | |
| Author | Obadia, Nathalie | |
| Author | Tavares, Juliana Carvalho | |
| Author | Freitas, Felipe Santos | |
| Author | Reis, Patricia Alves | |
| Author | Faria Neto, Hugo Castro | |
| Author | Lessa, Marcos Adriano | |
| Author | Tibiriça, Eduardo | |
| Access date | 2015-09-21T17:25:57Z | |
| Available date | 2015-09-21T17:25:57Z | |
| Document date | 2013 | |
| Citation | ESTATO, Vanessa; et al. Blockade of the renin–angiotensin system improves cerebral microcirculatory perfusion in diabetic hypertensive rats. Microvascular Research, v.87, p.41-49, 2013. | pt_BR |
| ISSN | 0026-2862 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11805 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Title | Blockade of the renin–angiotensin system improves cerebral microcirculatory perfusion in diabetic hypertensive rats | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.mvr.2013.02.007 | pt_BR |
| Abstract | We examined the functional and structural microcirculatory alterations in the brain, skeletal muscle and
myocardium of non-diabetic spontaneously hypertensive rats (SHR) and diabetic SHR (D-SHR), as well
as the effects of long-term treatment with the angiotensin AT1-receptor antagonist olmesartan and the
angiotensin-converting enzyme inhibitor enalapril. Diabetes was experimentally induced by a combination
of a high-fat diet with a single low dose of streptozotocin (35 mg/kg, intraperitoneal injection). D-SHR
were orally administered with olmesartan (5 mg/kg/day), enalapril (10 mg/kg/day) or vehicle for 28 days,
and compared with vehicle-treated non-diabetic SHR or normotensive non-diabetic Wistar–Kyoto rats. The
cerebral and skeletal muscle functional capillary density of pentobarbital-anesthetized rats was assessed
using intravital fluorescence videomicroscopy. Chronic treatment with olmesartan or enalapril significantly
lowered blood pressure and reversed brain functional capillary rarefaction. Brain oxidative stress was
reduced to non-diabetic control levels in animals treated with olmesartan or enalapril. Histochemical analysis
of the structural capillary density showed that both olmesartan and enalapril increased the capillary-to-fiber
ratio in skeletal muscle and the capillary-to-fiber volume density in the left ventricle. Olmesartan and enalapril
also prevented collagen deposition and the increase in cardiomyocyte diameter in the left ventricle. Our results
suggest that the association between hypertension and diabetes results in microvascular alterations in the brain,
skeletal muscle and myocardium that can be prevented by chronic blockade of the renin–angiotensin system. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Núcleo de Neurociências. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Renin–angiotensin system | pt_BR |
| Subject | Cerebral microcirculatory perfusion | pt_BR |
| Subject | Diabetic | pt_BR |
| Subject | hypertensive rats (SHR) | pt_BR |
| DeCS | Sistema Renina-Angiotensina | pt_BR |
| DeCS | Diabetes | pt_BR |
| DeCS | Ratos | pt_BR |
