| Author | Turetz, Meredith L | |
| Author | Machado, Paulo Roberto | |
| Author | Ko, Albert Icksang | |
| Author | Alves, Fábio | |
| Author | Bittencourt, Achilea Candida Lisboa | |
| Author | Almeida, Roque Pacheco de | |
| Author | Mobashery, Niloufar | |
| Author | Johnson Junior, Warren D | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Access date | 2015-10-14T18:38:38Z | |
| Available date | 2015-10-14T18:38:38Z | |
| Document date | 2002 | |
| Citation | TURETZ, M. L. et al. Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. Journal of Infectious Diseases, v. 186, n. 12, p. 1829-1834, 2002. | pt_BR |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11947 | |
| Language | eng | pt_BR |
| Publisher | University of Chicago, Press | pt_BR |
| Rights | open access | pt_BR |
| Title | Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. | pt_BR |
| Type | Article | pt_BR |
| Abstract | During the past decade, there has been an increase in the number of patients with disseminated leishmaniasis (DL), which is characterized by a large number of acneiform and papular skin lesions, with very few or no parasites in the skin tissue. The present report describes 42 cases of DL identified between 1992 and 1998 in an area where Leishmania braziliensis transmission is endemic; 8 of the patients were prospectively diagnosed. In a contrast to localized cutaneous leishmaniasis (LCL), acquisition of DL was associated with age >19 years (P<.05), male sex (P<.05), and agricultural occupation (P<.001). Patients with DL presented with 10-300 lesions that were a mixture of acneiform, papular, nodular, and ulcerated types. Twelve (29%) of 42 patients had mucosal involvement. Patients with DL had lower levels of interferon-gamma (P<.05) and tumor necrosis factor-alpha (P<.05) production, compared with patients with LCL. DL is an emerging clinical distinct form of leishmaniasis associated with agricultural activities and host immunological response | pt_BR |
| Affilliation | Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY / University of Maryland. Department of Internal Medicine. Baltimore, MD | pt_BR |
| Affilliation | Cornell University. Weill Medical College. New York Division of International Medicine and Infectious Diseases. New York, NY | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| DeCS | Leishmania braziliensis | pt_BR |
| DeCS | Leishmaniose Tegumentar Difusa/epidemiologia | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Idoso | pt_BR |
| DeCS | Agricultura | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Brasil/epidemiologia | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Interferon gama/biossíntese | pt_BR |
| DeCS | Leishmaniose Tegumentar Difusa/diagnóstico | pt_BR |
| DeCS | Leishmaniose Mucocutânea/diagnóstico | pt_BR |
| DeCS | Leucócitos Mononucleares/metabolismo | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Meia-Idade | pt_BR |
| DeCS | Membrana Mucosa/patologia | pt_BR |
| DeCS | Prevalência | pt_BR |
| DeCS | Fatores de Risco | pt_BR |
| DeCS | Pele/patologia | pt_BR |
| DeCS | Fator de Necrose Tumoral alfa/biossíntese | pt_BR |
