| Author | Nicol, A. F. | |
| Author | Grinsztein, B. | |
| Author | Friedman, R. K. | |
| Author | Veloso, V. G. | |
| Author | Cunha, C. B. | |
| Author | Georg, I. | |
| Author | Pilotto, J. H. | |
| Author | Moreira, R. I | |
| Author | Castro, C. A. V. | |
| Author | Silver, B. | |
| Author | Viscidi, R. P. | |
| Access date | 2015-10-19T13:25:06Z | |
| Available date | 2015-10-19T13:25:06Z | |
| Document date | 2013 | |
| Citation | NICOL, A. et al. Seroprevalence of HPV vaccine types 6, 11, 16 and 18 in HIV-infected and uninfected women from Brazil. J Clin Virol. v.52, n.3, p.265-8, Nov. 2013. | pt_BR |
| ISSN | 1386-6532 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11984 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | AIDS | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Gravidez | pt_BR |
| Subject in Portuguese | Vacinas | pt_BR |
| Title | Seroprevalence of HPV vaccine types 6, 11, 16 and 18 in HIV-infected and uninfected women from Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jcv.2013.02.007 | |
| Abstract | Background: Information on vaccine-type HPV seroprevalence is essential for vaccine strategies; however,
limited data are available on past exposure to HPV-quadrivalent vaccine types in HIV-infected woman
in Brazil.
Objectives: To assess the seroprevalence for HPV types 6, 11, 16 and 18 in HIV-infected and uninfected
women, from Rio de Janeiro, Brazil and to investigate potential associations with age and pregnancy
status.
Study-design: 1100-sera were tested by virus-like particle (VLPs)-based ELISA for antibodies to HPV types
16, 18, 6 and 11. Statistical analysis was carried out by STATA/SE 10.1 and comparisons among HIVinfected
and HIV-uninfected women were assessed by Poisson regression models with robust variance.
Results: HPV-6, 11, 16 and 18 seroprevalence was significantly higher among HIV-positive women (29.9%,
8.5%, 56.2% and 38.0%, respectively) compared to HIV-negative women (10.9%, 3.5%, 30.8% and 21.7%,
respectively), when adjusted by age and pregnancy status. Overall, 69.4% of HIV-infected and 41.5% of
HIV-uninfected women tested positive for any HPV quadrivalent vaccine type. However 4.7% and 1.1%,
respectively, tested positive for all HPV vaccine type. In HIV-uninfected women who were pregnant,
we found a higher HPV-11 seroprevalence (8.5% vs. 1.5%; P < 0.001) and a lower HPV 16 seroprevalence
(22.6% vs. 34.2%; P = 0.010) compared to not pregnant women. HIV-uninfected women, aged 40 or more
years old had a higher HPV 16 seroprevalence compared to women aged less than 40 years old.
Conclusions: We did not observe a strong association between age and positive HPV antibodies nor an
association between pregnancy and HPV seroprevalence. HPV seroprevalence was significantly higher
among HIV-infected women compared to HIV negative women. In both populations the seroprevalence
to all four HPV vaccine types was low suggesting that women may potentially benefit from the HPV
vaccines. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Medicina Interdisciplinar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Pediatrics. Baltimore, USA. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Pediatrics. Baltimore, USA. | pt_BR |
| Subject | HIV/AIDS | pt_BR |
| Subject | Pregnancy | pt_BR |
| Subject | VLP | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Q Vacinne | pt_BR |
| Subject | HPV seroprevalence | pt_BR |
| DeCS | Soroprevalência de HIV | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
