| Author | Tort, Luis Fernando López | |
| Author | Victoria, Matias | |
| Author | Lizasoain A, Andrés | |
| Author | Castella, Matías | |
| Author | Maya, Leticia | |
| Author | Gómez, Mariela Martínez | |
| Author | Arreseigor, Edit | |
| Author | López, Patricia | |
| Author | Cristina, Juan | |
| Author | Leite, José Paulo Gagliardi | |
| Author | Colina, Rodney | |
| Access date | 2015-11-03T10:49:09Z | |
| Available date | 2016-05-01T07:30:05Z | |
| Document date | 2015 | |
| Citation | TORT, Luis Fernando López; et al. Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12. Journal of Medical Virology, v.87, n.5, p.754–763, May 2015. | pt_BR |
| ISSN | 0146-6615 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12103 | |
| Language | eng | pt_BR |
| Publisher | Wiley Periodicals Inc. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Crianças | pt_BR |
| Subject in Portuguese | Genótipo G | pt_BR |
| Subject in Portuguese | Genótipo P | pt_BR |
| Subject in Portuguese | Uruguai | pt_BR |
| Title | Molecular Epidemiology of Group A Rotavirus Among Children Admitted to Hospital in Salto, Uruguay, 2011-2012: First Detection of the Emerging Genotype G12 | pt_BR |
| Type | Article | |
| DOI | 10.1002/jmv.24123 | |
| Abstract | Group A rotavirus (RVA) is the most important
etiologic agent of infant acute gastroenteritis
(AGE) worldwide. Detection and molecular
characterization of RVA in Salto department,
Northwestern region of Uruguay, was conducted
on 175 clinical samples, being 153 stool
and 22 vomit samples, collected from hospitalized
children with AGE, between 0–15 years
old, from two hospitals of Salto city during
2011 and 2012. RVA was detected and genotyped
by seminested multiplex RT-PCR in order
to determine G- and P-genotypes. Positive
samples were sequenced and phylogenetic
analyses were carried out in order to determine
lineages and sub-lineages. RVA were
detected in 64 (37%) of the samples and the G
and P genotypes observed were: 6% G1P[8],
23% G2P[4]/G2P[X]/GXP[4], 23% G3P[8]/G3P[X],
14% G12P[8]/G12P[X], 16% GXP[8], 1,5% G12P-
[9], 3% G2P[4]/[8], and 16% non-typeable. VP7
and VP4 genotypes related to DS-1 like gene
constellation were prevalent during 2011 and
those VP7 and VP4 genotypes related to Walike
constellation were prevalent during 2012
(mainly represented by G3P[8]). Interestingly,
RVA was detected in vomit samples in a high
prevalence (41%). RVA was observed mainly in
the age group between 1 and 5 years old (75%
of the cases), and seasonality with a high
detection rate in winter season was observed
for the two consecutive years of surveillance.
To our knowledge, this study represents the
first detection and molecular characterization
of RVA in Salto department, Northwestern
region of Uruguay; and the first identification
of the emerging genotype G12 in the country. | pt_BR |
| Affilliation | University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay. | pt_BR |
| Affilliation | University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay. | pt_BR |
| Affilliation | University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay. | pt_BR |
| Affilliation | University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay. | pt_BR |
| Affilliation | University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Medical-Surgical Society. Pediatric Unit.Salto, Uruguay. | pt_BR |
| Affilliation | Pediatric Unit of Regional Public Hospital. Salto, Uruguay. | pt_BR |
| Affilliation | University of Republic. Faculty of Sciences. Molecular Virology Laboratory. Salto, Uruguay. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Republic. North Regional. Molecular Virology Laboratory. Salto, Uruguay. | pt_BR |
| Subject | Group A rotavirus | pt_BR |
| Subject | hospitalized children | pt_BR |
| Subject | G- and P-genotypes | pt_BR |
| Subject | Salto; Uruguay | pt_BR |
| DeCS | Rotavirus | pt_BR |
| DeCS | Infecções por Rotavirus | pt_BR |
| DeCS | Gastroenterite | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2016-04-30 | |
