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Autor | Silva, Helen Aguiar Lemes da | |
Autor | Lima, Gabriel Silva de | |
Autor | Boité, Mariana Côrtes | |
Autor | Porrozzi, Renato | |
Autor | Hueb, Marcia | |
Autor | Damazo, Amilcar Sabino | |
Fecha de acceso | 2015-11-11T15:03:46Z | |
Fecha de disponibilización | 2015-11-11T15:03:46Z | |
Fecha de publicación | 2015 | |
Referencia | SILVA, Helen Aguiar Lemes da; et al. Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features. Rev. Soc. Bras. Med. Trop., v.48, n.5, p. 560-567, Sept./Oct. 2015. | pt_BR |
ISSN | 0037-8682 | |
URI | https://www.arca.fiocruz.br/handle/icict/12191 | |
Idioma | eng | pt_BR |
Editor | Sociedade Brasileira de Medicina Tropical | pt_BR |
Derechos de autor | open access | |
Título | Expression of annexin A1 in Leishmania-infected skin and its correlation with histopathological features | pt_BR |
Tipo del documento | Article | |
DOI | 10.1590/0037-8682-0183-2015 | |
Resumen en Inglés | Introduction: The aim of this study was quantify annexin A1 expression in macrophages and cluster of differentiation 4 (CD4)+ and cluster of differentiation 8 (CD8)+ T cells from the skin of patients with cutaneous leishmaniasis (n=55) and correlate with histopathological aspects. Methods: Infecting species were identifi ed by polymerase chain reaction-restriction fragment length polymorphism, and expression of annexin A1 was analyzed by immunofl uorescence. Results: All patients (n = 55) were infected with Leishmania braziliensis. Annexin A1 was expressed more abundantly in CD163+ macrophages in infected skin (p < 0.0001) than in uninfected skin. In addition, macrophages in necrotic exudative reaction lesions expressed annexin A1 at higher levels than those observed in granulomatous (p < 0.01) and cellular lesions p < 0.05). This difference might be due to the need to clear both parasites and necrotic tissue from necrotic lesions. CD4+ cells in cellular lesions expressed annexin A1 more abundantly than did those in necrotic (p < 0.05) and granulomatous lesions (p < 0.01). Expression in CD8+ T cells followed the same trend. These differences might be due to the pervasiveness of lymphohistiocytic and plasmacytic infi ltrate in cellular lesions. Conclusions: Annexin A1 is differentially expressed in CD163+ macrophages and T cells depending on the histopathological features of Leishmania-infected skin, which might affect cell activation. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso. Laboratório de Histologia. Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Histologia. Cuiabá, MT, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso. Faculdade de Medicina. Hospital Universitário Julio Müller. Cuiabá, MT, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso. Laboratório de Histologia. Pós-Graduação em Ciências da Saúde. Cuiabá, MT, Brasil / Universidade Federal de Mato Grosso. Faculdade de Medicina. Laboratório de Histologia. Cuiabá, MT, Brasil.. | pt_BR |
Palavras clave en Inglês | Cutaneous leishmaniasis | pt_BR |
Palavras clave en Inglês | Annexin A1 | pt_BR |
Palavras clave en Inglês | Lymphocytes | pt_BR |
Palavras clave en Inglês | Macrophages | pt_BR |
DeCS | Leishmaniose Cutânea | pt_BR |
DeCS | Linfócitos | pt_BR |
DeCS | Macrófagos | pt_BR |
DeCS | Anexina A1 | pt_BR |
e-ISSN | 1678-9849 |
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IOC - Artigos de Periódicos [12500]