| Author | Pedro, Heloisa da Silveira Paro | |
| Author | Nardi, Susilene Maria Tonelli | |
| Author | Pereira, Maria Izabel Ferreira | |
| Author | Oliveira, Rosângela Siqueira | |
| Author | Suffys, Philip Noel | |
| Author | Gomes, Harrison Magdinier | |
| Author | Finardi, Amanda Juliane | |
| Author | Moraes, Eloise Brasil de | |
| Author | Baptista, Ida Maria Foschiani Dias | |
| Author | Machado, Ricardo Luiz Dantas | |
| Author | Castiglioni, Lilian | |
| Access date | 2015-11-16T12:59:58Z | |
| Available date | 2015-11-16T12:59:58Z | |
| Document date | 2015 | |
| Citation | PEDRO, Heloisa da Silveira Paro; et al. Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis | pt_BR |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12235 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Title | Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-02760140316 | |
| Abstract | Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrugresistant
TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the
sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the
distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were
performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who
received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB
drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment,
but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which
are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but
tertiary healthcare is the most common entry point for patients into the system. These factors require special attention
from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases. | pt_BR |
| Affilliation | Instituto Adolfo Lutz. Centro de Laboratório Regional de São José do Rio Preto. Núcleo de Ciências Biomédicas. São José do Rio Preto, SP, Brasil / Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Genética. São José do Rio Preto, SP, Brasil. | pt_BR |
| Affilliation | Instituto Adolfo Lutz. Centro de Laboratório Regional de São José do Rio Preto. Núcleo de Ciências Biomédicas. São José do Rio Preto, SP, Brasil. | pt_BR |
| Affilliation | Instituto Adolfo Lutz. Centro de Laboratório Regional de São José do Rio Preto. Núcleo de Ciências Biomédicas. São José do Rio Preto, SP, Brasil | pt_BR |
| Affilliation | Instituto Adolfo Lutz Central. Núcleo de Tuberculose e Micobacterioses. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Lauro de Souza Lima. Divisão de Pesquisa e Ensino. Bauru, SP, Brasil. | pt_BR |
| Affilliation | Instituto Lauro de Souza Lima. Divisão de Pesquisa e Ensino. Bauru, SP, Brasil. | pt_BR |
| Affilliation | Instituto Lauro de Souza Lima. Divisão de Pesquisa e Ensino. Bauru, SP, Brasil. | pt_BR |
| Affilliation | Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Genética. São José do Rio Preto, SP, Brasil / Ministério da Saúde. Serviço de Vigilância em Saúde. Instituto Evandro Chagas. Departamento de Parasitologia. Belém, PA, Brasil. | pt_BR |
| Affilliation | Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Genética. São José do Rio Preto, SP, Brasil / Faculdade de Medicina de São José do Rio Preto. Departamento de Epidemiologia e Saúde Coletiva. São José do Rio Preto, SP, Brasil / Centro Universitário de São José do Rio Preto. Departamento de Biologia. São José do Rio Preto, SP, Brasil. | pt_BR |
| Subject | Tuberculosis | pt_BR |
| Subject | Diagnosis | pt_BR |
| Subject | Antimicrobial resistance | pt_BR |
| DeCS | Tuberculose | pt_BR |
| DeCS | Diagnóstico | pt_BR |
| DeCS | Antimicrobianos | pt_BR |
| DeCS | Resistência a Medicamentos | pt_BR |
| e-ISSN | 1678-8060 | |
