| Author | Rangel, Héctor R. | |
| Author | Bello, Gonzalo | |
| Author | Villalba, Julian A. | |
| Author | Sulbaran, Yoneira F. | |
| Author | Garzaro, Domingo | |
| Author | Maes, Mailis | |
| Author | Loureiro, Carmen L. | |
| Author | de Waard, Jacobus H. | |
| Author | Pujol, Flor H. | |
| Access date | 2015-12-08T13:29:04Z | |
| Document date | 2015 | |
| Citation | RANGEL, Héctor R. et al.The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains. AIDS Research and Human Retroviruses, v.31, n.12, p.1265-1268, Nov. 2015. | pt_BR |
| ISSN | 0889-2229 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12359 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Venezuela | pt_BR |
| Subject in Portuguese | Tuberculose | pt_BR |
| Title | The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1089/aid.2015.0155 | |
| Abstract | We previously reported a high prevalence of HIV-1 infection in Warao Amerindians from Venezuela due to the
rapid spread of a single B subtype strain. In this study we evaluated the coreceptor use of the HIV-1 strains
infecting this Amerindian community. Sequences of the HIV-1 V3 loop from 56 plasma samples were genotyped
for coreceptor use. An extremely high frequency of CXCR4 strains was found among HIV-1-infecting
Waraos (47/49, 96%), compared to HIV-1 strains infecting the non-Amerindian Venezuelan population (35/79,
44%, p < 0.00001). Evolutionary analysis showed that a significant number of infections occurred between 1 and
12 months before collection and that a great proportion (50–70%) of HIV-1 transmissions occurred within the
very early phase of infection (£12 months). This is consistent with an initial infection dominated by an X4 strain
or a very rapid selection of X4 variants after infection. This Amerindian population also exhibits the highest
prevalence of tuberculosis in Venezuela, being synergistically bad prognostic factors for the evolution of
morbidity and mortality in this vulnerable population. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto de Biomedicina. Laboratorio de Tuberculosis. Caracas, Venezuela / Harvard Medical School. Brigham and Women’s Hospital. Division of Pulmonary and Critical Care Medicine. Boston, Massachusetts, USA. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela. | pt_BR |
| Affilliation | Instituto de Biomedicina. Laboratorio de Tuberculosis. Caracas, Venezuela / University of Cambridge. Department of Medicine. Cambridge, United Kingdom. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela. | pt_BR |
| Affilliation | Instituto de Biomedicina. Laboratorio de Tuberculosis. Caracas, Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela. | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Warao Amerindians | pt_BR |
| Subject | Venezuela | pt_BR |
| Subject | AIDS | pt_BR |
| Subject | Tuberculosis | pt_BR |
| e-ISSN | 1931-8405 | |
| Embargo date | 2016-10-31 | |
