| Author | Silva, Lindomar dos Anjos | |
| Author | Divino, Flavia | |
| Author | Rêgo, Márlisson Octávio da Silva | |
| Author | Lopes, Ivina Geselle Lima | |
| Author | Costa, Cláudia Maria Nóbrega | |
| Author | Pereira, Francis Christian da Silva | |
| Author | de Filippis, Ivano | |
| Author | Bello, Gonzalo | |
| Access date | 2015-12-08T14:04:11Z | |
| Document date | 2015 | |
| Citation | SILVA, Lindomar dos Anjos; et al. HIV-1 Genetic Diversity and Transmitted Drug Resistance in Antiretroviral Treatment-Naive Individuals from Amapá State, Northern Brazil. AIDS Research and Human Retroviruses, ahead of print, Dec. 2015. | pt_BR |
| ISSN | 0889-2229 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12360 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Amapá | pt_BR |
| Title | HIV-1 Genetic Diversity and Transmitted Drug Resistance in Antiretroviral Treatment-Naive Individuals from Amapá State, Northern Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1089/aid.2015.0280 | |
| Abstract | The pattern of HIV-1 subtype distribution and prevalence of transmitted drug resistance mutations (TDRM) is heterogeneous across different Brazilian regions. Little information is available about the molecular epidemiologic profile in Northern Brazil. HIV-1 protease (PR) and reverse transcriptase (RT) sequences were obtained from 97 drug-naive HIV-1-infected individuals from Amapá, one of the most isolated Northern Brazilian states, for subtype determination and analysis of drug resistance mutations. The most prevalent HIV-1 clade observed in Amapá was subtype B (74%), followed by subtype F1 (14%), BF1 recombinants (8%), subtype C (1%), CRF31_BC (1%), and CRF02_AG (1%). Only one TDRM (K103N) was detected in a single patient from our study population. This study reveals that the HIV-1 epidemic in Amapá is characterized by a high level of genetic diversity comparable to that observed in major Brazilian cities, but a much lower rate of TDRM (1%). | pt_BR |
| Affilliation | Laboratório Central de Saúde Publica do Amapá (LACEN-AP). Macapá, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Laboratório Central de Saúde Publica do Amapá (LACEN-AP). Macapá, Brasil. | pt_BR |
| Affilliation | Laboratório Central de Saúde Publica do Amapá (LACEN-AP). Macapá, Brasil. | pt_BR |
| Affilliation | Laboratório Central de Saúde Publica do Amapá (LACEN-AP). Macapá, Brasil. | pt_BR |
| Affilliation | Laboratório Central de Saúde Publica do Amapá (LACEN-AP). Macapá, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde (INCQS). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Drug resistance mutations | pt_BR |
| Subject | Genetic diversity | pt_BR |
| DeCS | HIV-1 | pt_BR |
| DeCS | Resistência a Medicamentos | pt_BR |
| DeCS | Variação Genética | pt_BR |
| DeCS | Mutação | pt_BR |
| e-ISSN | 1931-8405 | |
| Embargo date | 2016-11-30 | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
