| Author | Pimentel, Victor F. | |
| Author | Morgado, Mariza F. | |
| Author | Bello, Gonzalo | |
| Author | Guimarães, Mark D. C. | |
| Author | Castilho, Euclides Ayres de | |
| Author | Veloso, Valdiléa G. | |
| Author | Guimarães, Monick L. | |
| Access date | 2015-12-08T15:36:23Z | |
| Available date | 2016-01-01T06:30:05Z | |
| Document date | 2013 | |
| Citation | PIMENTEL, Victor F. et al. Temporal Trends and Molecular Epidemiology of HIV Type 1 Infection in Rio de Janeiro, Brazil. AIDS Research and Human Retrovirises, v.29, n.12, p.1553-1561, 2013. | pt_BR |
| ISSN | 0889-2229 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12363 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert | pt_BR |
| Rights | open access | |
| Title | Temporal Trends and Molecular Epidemiology of HIV Type 1 Infection in Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1089/aid.2013.0050 | |
| Abstract | HIV-1 molecular epidemiology studies carried out in Rio de Janeiro, Brazil have identified the prevalence of subtypes B, F1 and BF1 recombinants. A high percentage of HIV-1 subtype B isolates in Rio de Janeiro harbor the GWG motif at the V3 tip (B′′ variant) instead of the canonical GPG motif (B variant). To trace the dynamics of the HIV-1 variants over time in different exposure categories in Rio de Janeiro, the HIV-1 proviral DNA from heterosexual men (HET) and men who have sex with men (MSM) from two distinct time periods (1990–1992 and 2008–2010) were extracted, and the env-gp120 region was amplified. Neighbor-joining phylogenetic analysis was performed to determine the viral subtype, and Bayesian analysis was used to trace the HIV-1 transmission networks. A predominance of subtype B was observed in both study periods, independent of the exposure risk category. An increase of non-B subtypes was observed in the HET group, but these subtypes were maintained among the MSM group. The distribution of HIV-1 subtype B signatures in the first and second periods studied were, respectively, HET (GPG) [44.8–51.5%], (GWG) [13.8–33.3%], and (GXG) [41.4–15.2%] and MSM (GPG) [34–50%], (GWG) [55.3–30.6%], and (GXG) [10.7–19.4%]. In the first period, an association between GWG and MSM was verified while a significant reduction of this association was observed during the second period. The phylogenetic tree and the BaTS program detected the clustering of isolates only according to the B signatures but not by exposure risk category. Our findings indicate a stable prevalence of HIV-1 subtypes B and F over time in Rio de Janeiro and further suggest that the B′′ subclade of subtype B was possibly introduced into the MSM group in this area of Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Molecular epidemiology | pt_BR |
| Subject | HIV Type 1 | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| Subject | Temporal trends | pt_BR |
| DeCS | Epidemiologia Molecular | pt_BR |
| DeCS | HIV - 1 | pt_BR |
| e-ISSN | 1931-8405 | |
| Embargo date | 2015-12-31 | |
