Author | Ramos, Klaysa Moreira | |
Author | Castro, Flávia Madeira Monteiro de | |
Author | Lacerda, Leandra Linhares | |
Author | Savino, Wilson | |
Access date | 2015-12-10T11:23:49Z | |
Available date | 2015-12-10T11:23:49Z | |
Document date | 2011 | |
Citation | RAMOS, Klaysa Moreira; et al. Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?. Mem Inst Oswaldo Cruz, v.106, n.6, p.759-762, Sept. 2011. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/12371 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | Can thymic epithelial cells be infected by human T-lymphotropic virus type 1? | pt_BR |
Type | Article | pt_BR |
Abstract | The human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic
epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might
be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1+-infected T cells
and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed
in TECs. After incubating TECs with culture supernatants from HTLV-1+-infected T cells, we detected gp46 on TEC
membranes and the HTLV-1 tax gene integrated in the TEC genome. In conclusion, the human thymic epithelium can
be infected in vitro by HTLV-1, not only via cell-cell contact, but also via exposure to virus-containing medium. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional do Câncer. Programa de Pós-Graduação em Oncologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual de Ciências da Saúde de Alagoas. Maceió, AL, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Thymic epithelial cells | pt_BR |
Subject | HTLV-1 infection | pt_BR |
Subject | Adult T cell leukaemia/lymphoma | pt_BR |
Subject | Cell adhesion | pt_BR |
DeCS | Adesão Celular | pt_BR |
DeCS | Células Epiteliais | pt_BR |
DeCS | Leucemia | pt_BR |
DeCS | Linforma | pt_BR |