Author | Rodrigues, Junia | |
Author | Grinsztejn, Beatriz | |
Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
Author | Velasque, Luciane | |
Author | Luz, Paula Mendes | |
Author | Souza, Claudia Teresa Vieira de | |
Author | Georg, Ingebourg | |
Author | Pilotto, Jose Henrique da Silva | |
Author | Veloso,Valdiléa G. | |
Access date | 2010-11-04T17:19:23Z | |
Available date | 2010-11-04T17:19:23Z | |
Document date | 2009 | |
Citation | RODRIGUES, Junia et al. Seroprevalence and factors associated with herpes simplex virus type 2 among HIV-negative high-risk men who have sex with men from Rio de Janeiro, Brazil: a cross-sectional study. BMC Infectious Diseases, v. 9, n. 39, p. 1-11, 2009. | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/1255 | |
Language | eng | en_US |
Rights | open access | en_US |
Title | Seroprevalence and factors associated with herpes simplex virus type 2 among HIV-negative high-risk men who have sex with men from Rio de Janeiro, Brazil: a cross-sectional study | en_US |
Type | Article | en_US |
Abstract | Background: Herpes simplex virus type 2 (HSV-2) is the leading cause of genital ulcer disease in
developing countries, including Brazil, and is especially prevalent among men who have sex with
men (MSM). HSV-2 infection represents a risk factor for the acquisition and transmission of other
sexually transmitted diseases. The goal of the present cross-sectional study was to estimate HSV-
2 seroprevalence and to determine the factors associated with HSV-2 seropositivity in HIVnegative
high-risk MSM from Rio de Janeiro, Brazil.
Methods: Stored sera were tested to estimate HSV-2 seroprevalence, while socio-demographic
and sexual behavior data were used to measure associations between risk factors and HSV-2
seropositivity. Using the Poisson regression model with robust variance, prevalence ratios (PR)
were used to estimate de degree of association between risk factors and HSV-2 seropositivity in
bivariate and multivariate analyses.
Results: Seroprevalence of HSV-2 was of 45.7% (184 out of 403). Factors independently associated
with HSV-2 seroprevalence in the multivariate model were: older age (≥ 26 years, PR: 1.41 95%
Confidence Interval: 1.11–1.78), non-white race (PR: 1.32 95%CI: 1.06–1.64), positive serology for
syphilis (PR: 1.65 95%CI: 1.33–2.05), positive serology for hepatitis B (PR: 1.25 95%CI: 0.99–1.57),
stable male partner in the past 6 months (PR: 1.42 95%CI: 1.12–1.79), and unprotected anal sex
with a stable female partner (PR: 1.46 95%CI: 1.05–2.04) in the 6 months preceding the crosssectional
assessment.
Conclusion: The present study made evident a high prevalence of HSV-2 infection in a sample of
HIV-negative high-risk MSM from Rio de Janeiro. This finding indicates the need and urgency for
implementing integrated programs for the prevention of HSV-2 and other sexually transmitted
diseases, and, in particular, programs targeting high-risk MSM. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Seroprevalence | en_US |
Subject | Herpes simplex virus type 2 | en_US |
Subject | HIV | en_US |
Subject | Risk factor | en_US |