| Author | Amancio, Rodrigo T. | |
| Author | Japiassu, Andre M. | |
| Author | Gomes, Rachel N. | |
| Author | Mesquita, Emersom C. | |
| Author | Assis, Edson F. | |
| Author | Medeiros, Denise M. | |
| Author | Grinsztejn, Beatriz | |
| Author | Bozza, Patrícia T. | |
| Author | Faria Neto, Hugo C. Castro | |
| Author | Bozza, Fernando A. | |
| Access date | 2016-01-26T13:27:56Z | |
| Available date | 2016-01-26T13:27:56Z | |
| Document date | 2013 | |
| Citation | AMANCIO, Rodrigo T. et al. The Innate Immune Response in HIV/AIDS Septic Shock Patients: A Comparative Study. Plos One, v.8, n.7, e68730, 8p, July 2013. | pt_BR |
| ISSN | 1932-6203 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12619 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Title | The Innate Immune Response in HIV/AIDS Septic Shock Patients: A Comparative Study | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0068730 | |
| Abstract | Introduction: In recent years, the incidence of sepsis has increased in critically ill HIV/AIDS patients, and the
presence of severe sepsis emerged as a major determinant of outcomes in this population. The inflammatory
response and deregulated cytokine production play key roles in the pathophysiology of sepsis; however, these
mechanisms have not been fully characterized in HIV/AIDS septic patients.
Methods: We conducted a prospective cohort study that included HIV/AIDS and non-HIV patients with septic shock.
We measured clinical parameters and biomarkers (C-reactive protein and cytokine levels) on the first day of septic
shock and compared these parameters between HIV/AIDS and non-HIV patients.
Results: We included 30 HIV/AIDS septic shock patients and 30 non-HIV septic shock patients. The HIV/AIDS
patients presented low CD4 cell counts (72 [7-268] cells/mm3), and 17 (57%) patients were on HAART before
hospital admission. Both groups were similar according to the acute severity scores and hospital mortality. The IL-6,
IL-10 and G-CSF levels were associated with hospital mortality in the HIV/AIDS septic group; however, the CRP
levels and the surrogates of innate immune activation (cytokines) were similar among HIV/AIDS and non-HIV septic
patients. Age (odds ratio 1.05, CI 95% 1.02-1.09, p=0.002) and the IL-6 levels (odds ratio 1.00, CI 95% 1.00-1.01,
p=0.05) were independent risk factors for hospital mortality.
Conclusions: IL-6, IL-10 and G-CSF are biomarkers that can be used to predict prognosis and outcomes in HIV/
AIDS septic patients. Although HIV/AIDS patients are immunocompromised, an innate immune response can be
activated in these patients, which is similar to that in the non-HIV septic population. In addition, age and the IL-6
levels are independent risk factors for hospital mortality irrespective of HIV/AIDS disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas (IPEC). Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas (IPEC). Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil / Instituto d’Or de Pesquisa e Ensino (IDOR). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas (IPEC). Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas (IPEC). Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas (IPEC). Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas (IPEC). Laboratório de HIV. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas (IPEC). Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil / Instituto d’Or de Pesquisa e Ensino (IDOR). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV/AIDS | pt_BR |
| Subject | Sepsis | pt_BR |
| Subject | Septic Shock | pt_BR |
| Subject | Innate Immune | pt_BR |
| Subject | Biomarkers | pt_BR |
| DeCS | Imunidade Inata | pt_BR |
| DeCS | Choque Séptico | pt_BR |
| DeCS | Sepse | pt_BR |
| DeCS | AIDS | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | Biomarcadores | pt_BR |
