| Author | Oliveira, Maria de Lourdes Aguiar | |
| Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
| Author | Dias, Paulo Roberto Telles Pires | |
| Author | Vilas-Boas Hacker, Mariana de Andrea | |
| Author | Oliveira, Sabrina Alberti Nóbrega de | |
| Author | Miguel, Juliana Custódio | |
| Author | Yoshida, Clara Fumiko Tachibana | |
| Access date | 2010-11-04T18:25:04Z | |
| Available date | 2010-11-04T18:25:04Z | |
| Document date | 2009 | |
| Citation | Journal of Clinical Virology 44 (2009) 200–206 | en_US |
| ISSN | 1386-6532 | |
| URI | https://www.arca.fiocruz.br/handle/icict/1261 | |
| Description | This paper is based on the data and experience obtained during
the WHO Drug Injection Study Phase II—a project, coordinated
and sponsored by the World Health Organization and implemented
by the WHO Phase II Drug Injection Collaborative Study
Group. The authors alone are responsible for the views expressed
in this paper, which do not necessarily represent those of the
other investigators participating in the WHO Drug Injection Study
Phase II nor the views or policy of the World Health Organization. We are grateful to the Harm Reduction Program team for the
fieldwork with such hard-to-reach and population; to Aline Santos
Moreira, from the Genomic Platform-DNA Sequencing (PDTISFiocruz)
for DNA sequencing of samples included in this study and
to Dr. José Paulo Leite, Dr.Milton Moraes, Mrs. Marcia Paschoal, and
Dr. Elisabeth Lampe, for their helpful suggestions. | en_US |
| Sponsorship | The Brazilian component of the study was sponsored by WHO,
as well as by the Coordenac¸ ão Geral de Laboratórios, National
Health Foundation, SVS, Ministry of Health and Conselho Nacional
de Desenvolvimento Científico e Tecnológico, CNPq, Grant no.
475668/03. | en_US |
| Language | eng | en_US |
| Publisher | Elsevier B.V. | en_US |
| Rights | open access | en_US |
| Title | Epidemiological and genetic analyses of Hepatitis C virus transmission among young/short- and long-term injecting drug users from Rio de Janeiro, Brazil | en_US |
| Type | Article | en_US |
| Abstract | Background: Injecting drug users (IDU) have a key role in Hepatitis C Virus (HCV) epidemiology.
Young/short-term IDUs constitute a target group for preventive/harm reduction interventions.
Objectives: To investigate HCV transmission among young/short-term (ST) and long-term (LT) IDUs, from
the perspective of epidemiology and molecular biology.
Study design: Cross-sectional study assessing the prevalence of HCV infection/genotypes, as well as risk
behaviours/practices among IDUs from Rio de Janeiro. Phylogenetic analyses were performed and the
extent of segregation between sequences was quantified by the Association Index.
Results: ST were more likely to engage into needle-sharing (p = .021) and LT to attend Needle Exchange
Programs (p = .006). HCV prevalence was 10.1% vs. 23.4% among initiates and LT, respectively (p < .001).
Older age vs. imprisonment and longer duration of IDU career were independent predictors for HCV
infection among ST and LT, respectively. Among the latter, NEP attendance was inversely associated with
viral infection. HCV3a infectionswere the most prevalent. A moderate extent of phylogenetic segregation
between sequences was found, suggestive of transmission between IDU subgroups.
Conclusions: The lower HCV prevalence among young/short-term IDUs cannot be viewed with complacency,
due to their frequent engagement into direct/indirect sharing practices and the ongoing
transmission between IDU subsets. To avert new infections, preventive/harm reduction policies must
be tailored to empirical findings. | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis & National Reference Laboratory for Influenza and Exanthematic Diseases, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | Oswaldo Cruz Foundation. Department of Health Information. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Harm Reduction Initiative (NEPAD), State University of Rio de Janeiro, Rio de Janeiro, Brazil | en_US |
| Affilliation | Laboratory of Leprosy, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Affilliation | National Reference Laboratory for Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil | en_US |
| Subject | Injecting drug use | en_US |
| Subject | Substance abuse | en_US |
| Subject | Hepatitis C virus | en_US |
| Subject | HCV epidemiology | en_US |
| Subject | HCV subtypes | en_US |
| Subject | Phylogenetic analysis | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
