Asthma is a chronic inflammatory disease whose prevalence has increased in the last 50 years. Several hormones can determine the course of asthma pathogenesis. Furthermore, some endocrine disorders, including diabetes and obesity, have been identified as important factors that influence the prevalence of asthma. These endocrine disorders are characterized by presenting an imbalance in blood hormones levels that regulate glucose metabolism, including hyperglycemic and hypoglycemic hormones. This review gives an update of the state-of-the-art concerning the effect of hormones that control glucose homeostasis on asthma pathogenesis and development. Here, we proposed that while hypoglycemic hormones, including insulin and leptin aggravate asthma, the hyperglycemic hormones, as glucagon, glucocorticoids and epinephrine, have a protective effect on asthma.