Author | Chakrabarti, Alokta | |
Author | Oehme, Ina | |
Author | Witt, Olaf | |
Author | Oliveira, Guilherme Correa de | |
Author | Sippl, Wolfgang | |
Author | Romier, Christophe | |
Author | Pierce, Raymond John | |
Author | Jung, Manfred | |
Access date | 2016-02-11T12:39:04Z | |
Available date | 2016-02-11T12:39:04Z | |
Document date | 2015 | |
Citation | CHAKRABARTI, Alokta et al. HDAC8: a multifaceted target for therapeutic interventions. Trends Pharmacol Sci., vol. 36, n. 7, p. 481-492, 2015. | pt_BR |
ISSN | 0165-6147 | |
URI | https://www.arca.fiocruz.br/handle/icict/12712 | |
Language | eng | pt_BR |
Publisher | Elsevier Inc | pt_BR |
Rights | open access | pt_BR |
Title | HDAC8: a multifaceted target for therapeutic interventions. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.tips.2015.04.013 | |
Abstract | Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections. It is a structurally well-characterized enzyme that also deacetylates nonhistone proteins. In cancer, HDAC8 is a major ‘epigenetic player’ that is linked to deregulated expression or interaction with transcription factors critical to tumorigenesis. In the parasite Schistosoma mansoni and in viral infections, HDAC8 is a novel target to subdue infection. The current challenge remains in the development of potent selective inhibitors that would specifically target HDAC8 with fewer adverse effects compared with pan-HDAC inhibitors. Here, we review HDAC8 as a drug target and discuss inhibitors with respect to their structural features and therapeutic interventions. | pt_BR |
Affilliation | Albert-Ludwigs-Universität Freiburg. Institute of Pharmaceutical Sciences. Freiburg, Germany | pt_BR |
Affilliation | German Cancer Research Centre. Clinical Cooperation Unit Pediatric Oncology. Heidelberg, Germany | pt_BR |
Affilliation | German Cancer Research Centre. Clinical Cooperation Unit Pediatric Oncology. Heidelberg, Germany/University Hospital Heidelberg. Department of Pediatric Oncology, Hematology and Immunology. Heidelberg, Germany | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Genômica e Biologia Computacional. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Martin-Luther-Universität Halle-Wittenberg. Institut für Pharmazie. Halle, Germany | pt_BR |
Affilliation | Université de Strasbourg. Institut de Génétique et Biologie Moléculaire et Cellulaire. Département de Biologie Structurale Intégrative. Illkirch, France | pt_BR |
Affilliation | Institut Pasteur de Lille. Université de Lille. Center for Infection and Immunity of Lille. Lille, France | pt_BR |
Affilliation | Albert-Ludwigs-Universität Freiburg. Institute of Pharmaceutical Sciences. Freiburg, Germany | pt_BR |
Subject | histone deacetylases | pt_BR |
Subject | HDAC8 | pt_BR |
Subject | Cornelia de Lange syndrome | pt_BR |
Subject | cancer | pt_BR |
Subject | schistosoma | pt_BR |
Subject | X-ray crystallography | pt_BR |