| Author | Costa, Pedro Augusto Carvalho | |
| Author | Leoratti, Fabiana Maria de Souza | |
| Author | Figueiredo, Maria Marta | |
| Author | Tada, Mauro Sughiro | |
| Author | Pereira, Dhelio Batista | |
| Author | Giusta, Caroline Junqueira | |
| Author | Soares, Irene da Silva | |
| Author | Barber, Daniel L. | |
| Author | Gazzinelli, Ricardo Tostes | |
| Author | Antonelli, Lis Ribeiro do Valle | |
| Access date | 2016-02-11T15:14:21Z | |
| Available date | 2016-02-11T15:14:21Z | |
| Document date | 2015 | |
| Citation | COSTA, Pedro Augusto Carvalho et al. Induction of inhibitory receptors on T cells during Plasmodium vivax malaria impairs cytokine production. J Infect Dis., vol. 212, n. 12, p. 1999-2010, 2015. | pt_BR |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12717 | |
| Language | eng | pt_BR |
| Publisher | Infectious Diseases Society of America | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Induction of inhibitory receptors on T cells during Plasmodium vivax malaria impairs cytokine production | pt_BR |
| Type | Article | |
| DOI | 10.1093/infdis/jiv306 | |
| Abstract | The function and regulation of the immune response triggered during malaria is complex and poorly understood, and there is a particular paucity of studies conducted in humans infected with Plasmodium vivax. While it has been proposed that T-cell-effector responses are crucial for protection against blood-stage malaria in mice, the mechanisms behind this in humans remain poorly understood. Experimental models of malaria have shown that the regulatory molecules, cytotoxic T-lymphocyte attenuator-4 (CTLA-4), lymphocyte activation gene-3 (LAG-3), and programmed death-1 (PD-1) are involved in the functional impairment of T cells during infection. Our goal was to define the role of these molecules during P. vivax malaria. We demonstrate that infection triggers the expression of regulatory molecules on T cells. The pattern of expression differs in CD4+ and CD8+ T cells. Higher frequencies of CD4+ express more than 1 regulatory molecule compared to CD8+ T cells. Moreover, lower proportions of CD4+ T cells coexpress regulatory molecules, but are still able to proliferate. Importantly, simultaneously blockade of the CLTA-4, PD-1, and T-cell immunoglobulin and mucin–3 signaling restores the cytokine production by antigen-specific cells. These data support the hypothesis that upregulation of inhibitory receptors on T cells during P. vivax malaria impairs parasite-specific T-cell effector function. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil | pt_BR |
| Affilliation | Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil | pt_BR |
| Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. T Lymphocyte Biology Unit. Bethesda, Maryland | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Immunopatologia. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | malaria | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
| Subject | regulatory molecules | pt_BR |
| Subject | T cells | pt_BR |
