| Author | Driguez, Patrick | |
| Author | McWilliam, Hamish E. G. | |
| Author | Gaze, Soraya | |
| Author | fita, David Piedra | |
| Author | Pearson, Mark S. | |
| Author | Nakajima, Rie | |
| Author | Duke, Mary | |
| Author | Trieu, Angela | |
| Author | Doolan, Denise L. | |
| Author | Cardoso, Fernanda C. | |
| Author | Jasinskas, Algis | |
| Author | Gobert, Geoffrey N. | |
| Author | Felgner, Philip L. | |
| Author | Loukas, Alex | |
| Author | Meeusen, Els | |
| Author | McManus, Donald P. | |
| Access date | 2016-02-16T13:19:22Z | |
| Available date | 2016-02-16T13:19:22Z | |
| Document date | 2015 | |
| Citation | DRIGUEZ, Patrick et al. Specific humoral response of hosts with variable schistosomiasis susceptibility. Immunology and Cell Biology, v. 94, n. 1, p. 52-65, 2016. | pt_BR |
| ISSN | 1440-1711 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12731 | |
| Language | eng | pt_BR |
| Publisher | Nature | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Specific humoral response of hosts with variable schistosomiasis susceptibility | pt_BR |
| Type | Article | |
| DOI | 10.1038/icb.2015.61 | |
| Abstract | The schistosome blood flukes are some of the largest global causes of parasitic morbidity. Further study of the specific antibody response during schistosomiasis may yield the vaccines and diagnostics needed to combat this disease. Therefore, for the purposes of antigen discovery, sera and antibody-secreting cell (ASC) probes from semi-permissive rats and sera from susceptible mice were used to screen a schistosome protein microarray. Following Schistosoma japonicum infection, rats had reduced pathology, increased antibody responses and broader antigen recognition profiles compared with mice. With successive infections, rat global serological reactivity and the number of recognized antigens increased. The local antibody response in rat skin and lung, measured with ASC probes, increased after parasite migration and contributed antigen-specific antibodies to the multivalent serological response. In addition, the temporal variation of anti-parasite serum antibodies after infection and reinfection followed patterns that appear related to the antigen driving the response. Among the 29 antigens differentially recognized by the infected hosts were numerous known vaccine candidates, drug targets and several S. japonicum homologs of human schistosomiasis resistance markers-the tegument allergen-like proteins. From this set, we prioritized eight proteins that may prove to be novel schistosome vaccine and diagnostic antigens. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Infectious Disease Division. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | University of Melbourne. Peter Doherty Institute for Infection and Immunity. Department of Microbiology and Immunology. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | James Cook University. Queensland Tropical Health Alliance Laboratory. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Cairns, Queensland, Australia / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Federation University. School of Applied Sciences and Engineering. Churchill, Victoria, Australia. | pt_BR |
| Affilliation | James Cook University. Queensland Tropical Health Alliance Laboratory. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Cairns, Queensland, Australia. | pt_BR |
| Affilliation | University of California Irvine. Division of Infectious Diseases. Department of Medicine. Irvine, CA, USA. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Infectious Disease Division. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Infectious Disease Division. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Infectious Disease Division. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Infectious Disease Division. Brisbane, Queensland, Australia/Institute for Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia. | pt_BR |
| Affilliation | University of California Irvine. Division of Infectious Diseases. Department of Medicine. Irvine, CA, USA. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Infectious Disease Division. Brisbane, Queensland, Australia. | pt_BR |
| Affilliation | University of California Irvine. Division of Infectious Diseases. Department of Medicine. Irvine, CA, USA. | pt_BR |
| Affilliation | James Cook University. Queensland Tropical Health Alliance Laboratory. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Cairns, Queensland, Australia. | pt_BR |
| Affilliation | Monash University. School of Biomedical Sciences. Department of Microbiology. Melbourne, Victoria, Australia. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Infectious Disease Division. Brisbane, Queensland, Australia. | pt_BR |
| Subject | Schistosome blood | pt_BR |
| Subject | S. japonicum | pt_BR |
