| Author | Carvalho, Ana Paula Mendes | |
| Author | Fabri, Angélica da Conceição Oliveira Coelho | |
| Author | Oliveira, Rodrigo Corrêa de | |
| Author | Lana, Francisco Carlos Félix | |
| Access date | 2016-02-26T19:05:36Z | |
| Available date | 2016-02-26T19:05:36Z | |
| Document date | 2015 | |
| Citation | CARVALHO, Ana Paula Mendes et al. Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases. BMC Infectious Diseases, v. 15, p. 1-8, 2015. | pt_BR |
| ISSN | 1471-2334 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12886 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | open access | pt_BR |
| Title | Factors associated with anti-phenolic glycolipid-I seropositivity among the household contacts of leprosy cases | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s12879-015-0955-3 | |
| Abstract | Background: The diagnosis of leprosy is based on clinical symptoms of the disease, which may not be sufficient to ensure early diagnosis. The development of effective tools for the early detection of infection, such as rapid tests that can be applied by non-specialists for early-stage leprosy identification, has been considered a research priority and may contribute to overcoming the complications associated with late diagnosis. The aim of this study was to analyze the factors associated with anti-phenolic glycolipid-I (PGL-I) seropositivity among the household contacts of leprosy cases. Methods: A cross-sectional study of individuals from the northeastern municipalities of the state of Minas Gerais, Brazil, was performed. Anti-PGL-I seropositivity was evaluated by assessing specific antibody production using the ML Flow test. A Poisson regression with a robust error variance was used to evaluate the relationship between anti-PGL-I seropositivity and the independent variables investigated. Results: The overall anti-PGL-I seropositivity was 13.5 %, and among the contacts of leprosy cases that were classified as paucibacillary or multibacillary, it was 8.4 and 17.3 %, respectively. The factors associated with the variation of anti-PGL-I seropositivity among the study population were the presence of signs suggestive of leprosy (PR = 3.68; 95 % CI: 1.56–8.71), the operational leprosy classification (PR = 2.17; 95 % CI: 1.22–3.86) and grade 1 (PR = 1.83; 95 % CI: 1.02–3.26) or grade 2 disability (PR = 2.42; 95 % CI: 1.02–5.47) of the index leprosy case. Conclusions: The presence of signs suggestive of leprosy and the operational classification of leprosy cases were associated with anti-PGL-I seropositivity. The serological tests available for leprosy are not considered to be diagnostic tests but can be used as auxiliary assessments in combination with clinical parameters to identify exposed individuals at high risk of developing leprosy and those exhibiting the initial stages of this disease. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Pós Graduação em Enfermagem Belo Horizonte, MG, Brasil / Universidade Federal de Juiz de Fora. Escola de Enfermagem. Departamento de Enfermagem Básica. Juiz de Fora, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil / Fundação Oswaldo. Centro de Pesquisa René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil / Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Laboratório de Imunologia. Ouro Preto, MG, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Pós-Graduação em Enfermagem. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Materno Infantil e Saúde Publica. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Leprosy Case | pt_BR |
| Subject | Slit Skin Smear | pt_BR |
| Subject | Leprosy Patient | pt_BR |
| Subject | Multibacillary Leprosy | pt_BR |
| Subject | Indeterminate Form | pt_BR |
| Subject | Operational Classification | pt_BR |
| Subject | BCG Vaccination Status | pt_BR |
| Subject | Smear Test | pt_BR |
| Subject | Paucibacillary Patient | pt_BR |
| Subject | Lepromatous Leprosy | pt_BR |
| Subject | Tuberculoid Form | pt_BR |
| Subject | Poisson Regression Model | pt_BR |
| Subject | Leprosy Control | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
