| Author | Porrozzi, Renato | |
| Author | Pereira, Miriam Sales | |
| Author | Teva, Antonio | |
| Author | Volpini, Angela Cristina | |
| Author | Pinto, Marcelo Alves | |
| Author | Marchevskyc, Renato Sergio | |
| Author | Barbosa Junior, Aryon de Almeida | |
| Author | Grimaldi Junior, Gabriel | |
| Access date | 2016-03-02T14:19:30Z | |
| Available date | 2016-03-02T14:19:30Z | |
| Document date | 2006 | |
| Citation | PORROZZI, R. et al. Leishmania infantum-induced primary and challenge infections in rhesus monkeys (Macaca mulatta): a primate model for visceral leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 100, p. 926-937, 2006. | pt_BR |
| ISSN | 0035-9203 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12943 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Title | Leishmania infantum-induced primary and challenge infections in rhesus monkeys (Macaca mulatta): a primate model for visceral leishmaniasis. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.trstmh.2005.11.005 | |
| Abstract | Visceral leishmaniasis (VL) was experimentally induced in rhesus macaques (Macaca
mulatta) by intravenously inoculating 2×107 amastigotes/kg of body weight of Leishmania
infantum. The macaques developed a systemic disease showing characteristic features of human
VL such as fever, diarrhoea, body weight loss, anaemia, hypergammaglobulinaemia and transient
lymphocytosis, as well as lymph node, liver and/or spleen enlargement. Nine weeks after
infection, one primate showed pronounced weight loss, became moribund and was euthanized.
The necropsy findings included granulomas composed of parasite-containing macrophages, lymphocytes
and plasma cells in the liver, spleen and lymph nodes. The remaining macaques had
a sustained course of infection but developed a mild-to-moderate illness that subsequently
showed evidence of self-cure. Of note, pathological findings included a typical cell-mediated
immunity-induced granulomatous reaction that had an effect on the control of parasite replication.
All infected monkeys responded with increased production of anti-Leishmania-specific
IgG antibodies. Despite the fact that clinical resistance to L. infantum was not consistently
associated with a parasite-specific cell-mediated immune response, drug-cured macaques from
the primary infection acquired immunity to homologous re-infection. These findings point to
the feasibility of using the L. infantum macaque model for pre-clinical evaluation of novel
chemotherapeutics or vaccine candidates for human VL. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Neurovirulência. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Unidade de Histopatologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Visceral leishmaniasis | pt_BR |
| Subject | Leishmania infantum | pt_BR |
| Subject | Macaca mulatta | pt_BR |
| Subject | Immune responses | pt_BR |
| Subject | Histopathology | pt_BR |
| Subject | Treatment | pt_BR |
| DeCS | Modelos Animais de Doenças | pt_BR |
| DeCS | Leishmania infantum/imunologia | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Anticorpos Antiprotozoários/sangue | pt_BR |
| DeCS | Formação de Anticorpos | pt_BR |
| DeCS | Antígenos de Protozoários/sangue | pt_BR |
| DeCS | DNA de Protozoário/análise | pt_BR |
| DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
| DeCS | Doenças Hematológicas/parasitologia | pt_BR |
| DeCS | Imunidade Celular | pt_BR |
| DeCS | Leishmaniose Visceral/sangue | pt_BR |
| DeCS | Macaca mulatta | pt_BR |
