| Author | Miguel, Fúlvio Borges | |
| Author | Cardoso, Ana Karina M. V | |
| Author | Barbosa Junior, Aryon de Almeida | |
| Author | Marcantonio Junior, Elcio | |
| Author | Goissis, Gilberto | |
| Author | Rosa, Fabiana Paim | |
| Access date | 2016-03-02T17:55:09Z | |
| Available date | 2016-03-02T17:55:09Z | |
| Document date | 2006 | |
| Citation | MIGUEL, F. B. et al. Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. Journal of Biomedical Materials Research Part B: Applied Biomaterials, v. 78B, p. 334-339, 2006. | pt_BR |
| ISSN | 1552-4973 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12944 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Title | Morphological assessment of the behavior of three-dimensional anionic collagen matrices in bone regeneration in rats. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1002/jbm.b.30492 | |
| Abstract | The osteogenic behavior of three-dimensional collagenic and anionic matrices
(M3DGA) implanted in critical bone defects of 8 mm diameter was morphologically assessed.
The defects were performed in the calvaria of 48 adult male (Wistar) rats, and observed at
days 15, 30, and 60. The animals were distributed in four groups of equal number: GA1
(M3DGA with 60 min of cross-linking in glutaraldehyde [GA]); GA2 (M3DGA with 30 min of
cross-linking in GA); GA3 (M3DGA with 15 min of cross-linking in GA); and G4 (control
group, without any implanted biomaterial). The M3DGAs were biocompatible, with mild and
regressive chronic granulomatous inflammation, associated with the degradation of their
fibers. Furthermore, tissue neovascularization and neomineralization was noted, with statistically
significant differences in these amounts among the groups (GA1, GA2, and GA3) and
G4. In G4 neoformation was limited to the edges of the defect as well as interstitial fibrosis.
Under the experimental conditions and for the parameters analyzed, the M3DGAs had
osteogenic behavior, which was more evident in M3DGA 15 min | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | State Paulista University. Dentistry Faculty. Araraquara, SP, Brasil | pt_BR |
| Affilliation | University of São Paulo. Chemistry Department. São Carlos, SP, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Health Sciences Institute. Salvador, BA, Brasil | pt_BR |
| Subject | Tissue bioengineering | pt_BR |
| Subject | Anionic collagen | pt_BR |
| Subject | Three-dimensional matrix | pt_BR |
| Subject | Bone regeneration | pt_BR |
| Subject | Critical size defect | pt_BR |
| DeCS | Regeneração Óssea | pt_BR |
| DeCS | Substitutos Ósseos | pt_BR |
| DeCS | Calcificação Fisiológica | pt_BR |
| DeCS | Colágeno | pt_BR |
| DeCS | Regeneração Tecidual Guiada | pt_BR |
| DeCS | Neovascularização Fisiológica | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Substitutos Ósseos/efeitos adversos | pt_BR |
| DeCS | Colágeno/efeitos adversos | pt_BR |
| DeCS | Traumatismos Craniocerebrais/terapia | pt_BR |
| DeCS | Regeneração Tecidual Guiada/efeitos adversos | pt_BR |
| DeCS | Ratos | pt_BR |
