| Author | Pereira, Glaucia Vilar | |
| Author | Ruivo, Leonardo Alexandre de Souza | |
| Author | Vieira, Joseli Lannes | |
| Access date | 2016-03-03T16:39:59Z | |
| Available date | 2016-03-03T16:39:59Z | |
| Document date | 2015 | |
| Citation | PEREIRA, Glaucia Vilar; RUIVO, Leonardo Alexandre de Souza; VIEIRA, Joseli Lannes. Behavioural alterations are independent of sickness behaviour in chronic experimental Chagas disease. Memórias do Instituto Oswaldo Cruz, v.110, n.8, p.1040-1052, Dec. 2015. | pt_BR |
| ISSN | 1678-8060 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12964 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Alterações comportamentais | pt_BR |
| Title | Behavioural alterations are independent of sickness behaviour in chronic experimental Chagas disease | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-02760150300 | |
| Abstract | The existence of the nervous form of Chagas disease is a matter of discussion since Carlos Chagas described neurological disorders, learning and behavioural alterations in Trypanosoma cruzi-infected individuals. In most patients, the clinical manifestations of the acute phase, including neurological abnormalities, resolve spontaneously without apparent consequence in the chronic phase of infection. However, chronic Chagas disease patients have behavioural changes such as psychomotor alterations, attention and memory deficits, and depression. In the present study, we tested whether or not behavioural alterations are reproducible in experimental models. We show that C57BL/6 mice chronically infected with the Colombian strain of T. cruzi (150 days post-infection) exhibit behavioural changes as (i) depression in the tail suspension and forced swim tests, (ii) anxiety analysed by elevated plus maze and open field test sand and (iii) motor coordination in the rotarod test. These alterations are neither associated with neuromuscular disorders assessed by the grip strength test nor with sickness behaviour analysed by temperature variation sand weight loss. Therefore, chronically T. cruzi-infected mice replicate behavioural alterations (depression and anxiety) detected in Chagas disease patients opening an opportunity to study the interconnection and the physiopathology of these two biological processes in an infectious scenario. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Behavioural alterations | pt_BR |
| Subject | Sickness behaviour | pt_BR |
| Subject | Depression | pt_BR |
| Subject | Anxiety | pt_BR |
| DeCS | Trypanosoma cruzi | pt_BR |
| DeCS | Doença de Chagas | pt_BR |
| DeCS | Depressão | pt_BR |
| DeCS | Ansiedade | pt_BR |
