Author | Araújo, Caliandra Pinto | |
Author | Gurgel, Clarissa Araújo Silva | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Freitas, Valéria Souza | |
Author | Barbosa Junior, Aryon de Almeida | |
Author | Ramalho, Luciana Maria Pedreira | |
Author | Santos, Jean Nunes dos | |
Access date | 2016-03-03T17:20:58Z | |
Available date | 2016-03-03T17:20:58Z | |
Document date | 2010 | |
Citation | ARAÚJO, C. P. et al. Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis. Journal of Molecular Histology, v. 41, p. 357-365, 2010. | pt_BR |
ISSN | 1567-2379 | |
URI | https://www.arca.fiocruz.br/handle/icict/12968 | |
Language | eng | pt_BR |
Publisher | Springer Verlag | pt_BR |
Rights | open access | pt_BR |
Title | Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1010.1007/s10735-010-9297-z07/s10735-010-9297-z | |
Abstract | LCs and MCs are known to be directly influenced
by UV radiation. This study investigated the presence
of Langerhans cells (LCs) and mast cells (MCs) in
actinic cheilitis (AC) exhibiting epithelial dysplasia (ED).
Using immunohistochemistry for CD1a and mast cell
tryptase, LCs and MCs density was assessed in 35 cases of
AC with different degrees of ED. LCs were found in 32
cases of AC whereas MCs were found in all cases. There
was an increase in LCs density irrespective of degree of ED
when the cases were compared to normal lip mucosa
(P = 0.04343). No statistical difference in LCs density was
observed regarding the different degrees of dysplasia
(P[0.05). Significant difference in MCs density between
mild and moderate dysplasia and normal lip mucosa was
found (P\0.05). No significant correlation between LCs
and MCs was seen (P = 0.1258). Although no correlation
could be established between LCs and MCs and the different
degrees of ED; it is possible that the accumulation of
LCs plays an immunostimulatory and protective role in the
defense against progression of dysplasia. Further studies
are necessary to determine the role of MCs in the development
of AC. | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Oral Pathology, Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | State University of Feira de Santana. Department of Health. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | State University of Feira de Santana. Department of Stomatology. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Department of Oral Pathology, Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
Subject | Actinic chelitis | pt_BR |
Subject | Langerhans cells | pt_BR |
Subject | Mast cells | pt_BR |
Subject | Epithelial dysplasia | pt_BR |