| Autor | Menezes, Ana Paula de Oliveira | |
| Autor | Azevedo, Jailton | |
| Autor | Leite, Mariela C | |
| Autor | Campos, Leila Carvalho | |
| Autor | Cunha, Marcelo | |
| Autor | Carvalho, Maria da Gloria S | |
| Autor | Reis, Mitermayer Galvão dos | |
| Autor | Ko, Albert Icksang | |
| Autor | Weinberger, Daniel M | |
| Autor | Ribeiro, Guilherme de Sousa | |
| Autor | Reis, Joice Neves | |
| Data de acesso | 2016-03-04T18:58:18Z | |
| Data de disponibilização | 2016-03-04T18:58:18Z | |
| Data do publicação | 2016 | |
| Citação | MENEZES, A. P. O. Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction. Vaccine, v. 34, n. 6, p. 791-797, 2016. | pt_BR |
| ISSN | 0264-410X | |
| ISSN | dx.doi.org/10.1016/j.vaccine.2015.12.042 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13029 | |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Direito Autoral | open access | pt_BR |
| Título | Nasopharyngeal carriage of Streptococcus pneumoniae among childrenin an urban setting in Brazil prior to PCV10 introduction | pt_BR |
| Tipo do documento | Article | pt_BR |
| Resumo em Inglês | tInformation on pneumococcal carriage in the pre-vaccine period is essential to predict and assess theimpact of PCV in settings where disease surveillance is particularly difficult. Therefore, we present dataon pneumococcal carriage before the introduction of the 10-valent-pneumococcal conjugate vaccine(PCV10) in Brazil. We conducted a prospective study on a cohort of 203 children aged <5 years old,randomly selected in an urban community located in the periphery of the city of Salvador, Brazil andfollowed them from January/2008 to January/2009. Nasopharyngeal swabs were collected from eachchild at four times. In total, 721 swabs were collected, yielding a pneumococcal carriage prevalence of55% (n = 398). In multivariate analyses, the variables associated with carriage were having contact withthree or more children <2 years old (OR, 2.00; 95% CI 1.33–2.89) and living in a house with an averageof 3 residents per room (OR, 1.77; 95% CI 1.05–3.10). Also, white participants were more likely to beprotected from colonization (OR, 0.52; 95% CI 0.29–0.93), and prevalence of carriage varied over time,with lower prevalence occurring from February to June (OR, 0.53; 95% CI 0.37–0.78) compared to Julyto January. Contact with children under 2 years of age and living in crowded housing also were associ-ated with colonization by highly invasive serotypes, although this relationship was not significant. Themost prevalent vaccine serotypes were 6A/B (25.4%), 19F (10.1%) and 14 (9.0%), while the most preva-lent non-vaccine serotypes were 16F (4.8%), 15B/C (4.5%) and 6C/D (3.5%). Overall, 38.4% (153/398) ofthe isolates were non-susceptible to penicillin, and of those, 73.8% (113/153) were non-susceptible totrimethoprim/sulfamethoxazole. Colonization rate by PCV10 serotypes was 52.2%. Routine PCV10 vacci-nation can lead to significant changes in pneumococcal serotypes found in NP colonization, indicating aneed for continued monitoring, especially in crowded settings, as occurs in Brazil’s slums. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliação | Centers for Disease Control & Prevention. Respiratory Diseases Branch. Atlanta, GA, USA | pt_BR |
| Afiliação | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USA | pt_BR |
| Afiliação | Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, USA | pt_BR |
| Afiliação | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil | pt_BR |
| Palavras-chave em inglês | Children | pt_BR |
| Palavras-chave em inglês | Nasopharyngeal carriage | pt_BR |
| Palavras-chave em inglês | Streptococcus pneumoniae | pt_BR |
| Palavras-chave em inglês | Serotypes | pt_BR |
| Palavras-chave em inglês | PCV10-vaccine | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
