| Author | Chissumba, Raquel Matavele | |
| Author | Barbosa, Suse Dayse Silva | |
| Author | Augusto, Ângelo | |
| Author | Mauela, Cremildo | |
| Author | Mabunda, Nédio | |
| Author | Gudo Jr, Eduardo Sarno | |
| Author | Bhatt, Nilesh | |
| Author | Jani, Ilesh | |
| Author | Savino, Wilson | |
| Access date | 2016-03-08T14:26:31Z | |
| Available date | 2016-03-08T14:26:31Z | |
| Document date | 2015 | |
| Citation | CHISSUMBA, Raquel Matavele; et al. CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor. BMC Immunology, v.16:52, 9p, 2015. | pt_BR |
| ISSN | 1471-2172 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13052 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Infecções por HTLV | pt_BR |
| Subject in Portuguese | Neuropatias | pt_BR |
| Subject in Portuguese | Infecções por HIV | pt_BR |
| Title | CD4+ CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor | pt_BR |
| Type | Article | |
| DOI | 10.1186/s12865-015-0116-x | |
| Abstract | Background: Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system.
Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development
of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-infection are more
prone to develop neurological complications. The aim of this study was to characterize phenotypically Treg cells in
HIV-1/HTLV-1 co-infected Mozambican individuals presenting neurological symptoms.
Methods: A cross-sectional study was conducted among HIV-infected individuals presentingneurological symptoms, with
and without HTLV co-infection, and blood donors. Peripheral bloodmononuclear cells were stained with monoclonal
antibodies conjugated with fluorochromes to quantifyTregs and activated T cells by four colors flow cytometry.
Results: Higher Treg cell frequency (10.6 %) was noted in HIV-1/HTLV-1 co-infected group with neurological
symptoms when compared to HIV-1 mono-infected group with neurological symptoms (0.38 %, p = 0.003) and
control group (0.9 %, p = 0.0105). An inverse correlation between Foxp3 and CD49d expression was observed
in all study groups (rh = −0.71, p = 0.001). In addition, increased levels of Treg cells in co-infected patients
were strongly associated with total activated CD4 T cells (rh = 0.8, p = 0.01).
Conclusion: Treg cells in co-infected patients present phenotypic alterations and might have dysfunction marked by
low expression of Foxp3 and increased expression of molecules not frequently seen on Treg cells, such as CD49d.
These alterations may be related to (1) changes in Treg cell trafficking and migration, possibly making those cells
susceptible to HIV infection, and (2) inability to control the activation and proliferation of effector T lymphocytes. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Health. Maputo, Mozambique. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Health. Maputo, Mozambique. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Health. Maputo, Mozambique. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Health. Maputo, Mozambique. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Health. Maputo, Mozambique. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Health. Maputo, Mozambique. | pt_BR |
| Affilliation | Ministry of Health. National Institute of Health. Maputo, Mozambique. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV/HTLV Co-infected patients | pt_BR |
| Subject | Neuropathy | pt_BR |
| Subject | Foxp3 transcription factor | pt_BR |
| Subject | CD4+ CD25High Treg cells | pt_BR |
| Subject | Alpha4 integrin | pt_BR |
