| Author | Brasil, Patrícia | |
| Author | Pereira, José P. | |
| Author | Gabaglia, Claudia Raja | |
| Author | Damasceno, Luana | |
| Author | Wakimoto, Mayumi | |
| Author | Nogueira, Rita M. Ribeiro | |
| Author | Sequeira, Patrícia Carvalho de | |
| Author | Siqueira, André Machado | |
| Author | Carvalho, Liege M. Abreu de | |
| Author | Cunha, Denise Cotrim da | |
| Author | Calvet, Guilherme A. | |
| Author | Neves, Elizabeth S. | |
| Author | Moreira, Maria E. | |
| Author | Baião, Ana E. Rodrigues | |
| Author | Carvalho, Paulo R. Nassar de | |
| Author | Janzen, Carla | |
| Author | Valderramos, Stephanie G. | |
| Author | Cherry, James D. | |
| Author | Filippis, Ana M. Bispo de | |
| Author | Nielsen-Saines, Karin | |
| Access date | 2016-03-09T11:54:02Z | |
| Available date | 2016-03-09T11:54:02Z | |
| Document date | 2016 | |
| Citation | BRASIL, Patrícia et al. Zika virus infection in pregnant women in Rio de Janeiro: preliminary report. The New England Journal of Medicine, Massachusetts, March 8, p. 1-11, 2016. | pt_BR |
| ISSN | 0028-4793 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13063 | |
| Description | Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htm | pt_BR |
| Description | Versão final do artigo - handle https://www.arca.fiocruz.br/handle/icict/17780 | pt_BR |
| Language | por | pt_BR |
| Publisher | Massachusetts Medical Society | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Vírus Zika | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Doença ZIKV na gravidez | pt_BR |
| Subject in Portuguese | Aedes aegypti | pt_BR |
| Title | Zika virus infection in pregnant women in Rio de Janeiro: preliminary report | pt_BR |
| Type | Article | |
| DOI | 10.1056/NEJMoa1602412 | |
| Abstract | BACKGROUND
Zika virus (ZIKV) has been linked to neonatal microcephaly. To characterize the spectrum of ZIKV disease in pregnancy, we followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in fetuses.
METHODS
We enrolled pregnant women in whom a rash had developed within the previous 5 days
and tested blood and urine specimens for ZIKV by reverse-transcriptase–polymerasechain-reaction
assays. We followed the women prospectively and collected clinical and
ultrasonographic data. RESULTS A total of 88 women were enrolled from September 2015 through February 2016; of these 88 women, 72 (82%) tested positive for ZIKV in blood, urine, or both. The timing
of acute ZIKV infection ranged from 5 to 38 weeks of gestation. Predominant clinical features included pruritic descending macular or maculopapular rash, arthralgias, conjunctival injection, and headache; 28% had fever (short-term and low-grade).Women who were positive for ZIKV were more likely than those who were negative for the virus to have maculopapular rash (44% vs. 12%, P=0.02), conjunctival involvement (58% vs. 13%, P=0.002), and lymphadenopathy (40% vs. 7%, P=0.02). Fetal ultrasonography was performed in 42 ZIKV-positive women (58%) and in all ZIKV-negative women. Fetal abnormalities were detected by Doppler ultrasonography in 12 of the 42 ZIKV-positive women (29%) and in none of the 16 ZIKV-negative women. Adverse findings
included fetal deaths at 36 and 38 weeks of gestation (2 fetuses), in utero growth
restriction with or without microcephaly (5 fetuses), ventricular calcifications or other central nervous system (CNS) lesions (7 fetuses), and abnormal amniotic fluid volume or cerebral or umbilical artery flow (7 fetuses). To date, 8 of the 42 women in whom fetal ultrasonography was performed have delivered their babies, and the ultrasonographic findings have been confirmed. CONCLUSIONS Despite mild clinical symptoms, ZIKV infection during pregnancy appears to be associated
with grave outcomes, including fetal death, placental insufficiency, fetal growth restriction, and CNS injury. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Biomedical Research Institute of Southern California. Oceanside, California, EUA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine, Los Angeles, EUA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine, Los Angeles, EUA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine, Los Angeles, EUA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine, Los Angeles, EUA. | pt_BR |
| Subject | Zika Virus | pt_BR |
| Subject | Microcephaly | |
| Subject | ZIKV disease in pregnancy | |
| Subject | Aedes aegypti | |
| DeCS | Aedes | pt_BR |
| DeCS | Microcefalia | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
