| Author | Teixeira, Eliane de Morais | |
| Author | Aguiar, Marta Gontijo | |
| Author | Lima, Bruna Soares de Souza | |
| Author | Ferreira, Lucas Antonio Miranda | |
| Author | Rabello, Ana Lucia Teles | |
| Access date | 2016-03-10T12:12:15Z | |
| Available date | 2016-03-10T12:12:15Z | |
| Document date | 2015 | |
| Citation | TEIXEIRA, Eliane de Morais et al. Combined suboptimal schedules of topical paromomycin, meglumine antimoniate and miltefosine to treat experimental infection caused by Leishmania (Viannia) braziliensis. J Antimicrob Chemother.,vol. 70, n. 12. p. 3283-3290, 2015. | pt_BR |
| ISSN | 1460-2091 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13069 | |
| Language | eng | pt_BR |
| Publisher | Oxford journals | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Combined suboptimal schedules of topical paromomycin, meglumine antimoniate and miltefosine to treat experimental infection caused by Leishmania (Viannia) braziliensis. | pt_BR |
| Type | Article | |
| DOI | 10.1093/jac/dkv254 | |
| Abstract | Objectives: This study aimed to evaluate the efficacy of binary combinations of suboptimal schedules of drugs with different administration routes (topical paromomycin, intramuscular meglumine antimoniate and oral miltefosine) to treat animals infected with Leishmania (Viannia ) braziliensis .
Methods: Hamsters were inoculated with L.(V.) braziliensis and after ulceration of lesions, divided into seven groups: untreated control, paromomycin, miltefosin e, meglumine antimoniate, meglumine antimoniate + paromomycin, miltefosine + paromomycin and meglumine antimoniate + miltefosine. Meglumine antimoniate and miltefosine were administered at low doses and topical paromomycin at a single daily application regimen. The animals were treated for 20 consecutive days (meglumine antimoniate and/or paromomycin) and/or 10 alternate days (miltefosine). Lesion sizes were determined weekly. Upon completion of treatment, parasites were recovered from skin lesions and spleens and evaluated by limiting dilution assay.
Results: The combinations of a once daily application of paromomycin with low doses of miltefosine or meglumine antimoniate yielded higher efficacies in reducing the parasite load as well as lesion size when compared with any of these drugs administered as monotherapy regimens at the same suboptimal schedules.
Conclusions: Considering the parameters evaluated, the combinations of a systemic therapy with topical treatment were more effective than monotherapy with each of these drugs. These combinations may represent na alternative combination strategy for the treatment of leishmaniasis caused by L.(V.) braziliensis | pt_BR |
| Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, Brasil/Univerdidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento de Farmaceuticos. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Univerdidade Federal de Minas Gerais. Faculdade de Farmacia. Departamento de Farmaceuticos. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundaçao Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisas Clınicas. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Leishmania (Viannia ) braziliensis | pt_BR |
