| Author | Cambou, Mary C. | |
| Author | Levi, José Eduardo | |
| Author | Lake, Jordan E. | |
| Author | Andrade, Angela de | |
| Author | Jalil, Emilia M. | |
| Author | Russomano, Fabio | |
| Author | Derrico, Mônica | |
| Author | Veloso, Valdiléa G. | |
| Author | Friedman, Ruth K. | |
| Author | Luz, Paula M. | |
| Author | Grinsztejn, Beatriz | |
| Access date | 2016-04-04T14:32:21Z | |
| Available date | 2016-04-04T14:32:21Z | |
| Document date | 2015 | |
| Citation | CAMBOU, Mary C. et al. Time Trend Analysis of Cervical High-Risk HPV in HIV-Infected Women in an Urban Cohort from Rio de Janeiro, Brazil: The Rise of Non-16/18 HPV. International Journal of Infectious Diseases, v. 41, p. 1-8, Dec. 2015. | |
| ISSN | 1201-9712 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13517 | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Later version | https://www.arca.fiocruz.br/handle/icict/29647 | |
| Rights | open access | |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Women | pt_BR |
| Subject in Portuguese | Cervical HPV | pt_BR |
| Title | Time Trend Analysis of Cervical High-Risk HPV in HIV-Infected Women in an Urban Cohort from Rio de Janeiro, Brazil: The Rise of Non-16/18 HPV | en_US |
| Type | Preprint | |
| DOI | 10.1016/j.ijid.2015.10.017 | |
| Abstract | Objectives: HIV-infected women are at increased risk of human papillomavirus (HPV) infection. Time trends in annual prevalences of cervical high-risk human papillomavirus (HR-HPV) genotypes among a non-vaccinated, HIV-infected female cohort in urban Brazil were assessed for the period 2006-2012. Methods: Cervical specimens were collected for HPV genotyping yearly between January 2006 and December 2012 in a cross-sectional analysis of participants aged ≥18 years enrolled in the Women's HIV Cohort at Fiocruz in Rio de Janeiro, Brazil. Age-adjusted generalized estimating equation models with an exchangeable matrix were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for annual HPV positivity (reference year: 2006). Results: Among the 590 participants, the median age across all study years ranged from 35.5 to 40.0 years. The prevalence of any HR-HPV was ≥53% every year; prevalences of HR-HPV 16, 58, 59, and 68 were ≥24% in at least 1 year. The odds of HPV 16 and 68 decreased in 2012. HPV 58 prevalence followed a U-shape, beginning and ending at >20%. HPV 59 prevalence followed a linear trend, with increased odds in 2012 (OR 16.0, 95% CI 3.8-67.3; Bonferroni-adjusted p-value <0.01). Conclusions: The prevalences of HR-HPV 58, 59, and 68 were high in this cohort. Given current HR-HPV vaccine coverage and availability, further investigations are needed to optimize vaccine recommendations for this population. | en_US |
| Affilliation | Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório de Virologia. São Paulo, SP, Brasil. | |
| Affilliation | UCLA David Geffen School of Medicine. Department of Medicine. Division of Infectious Diseases. Program in Global Health. Los Angeles, CA, USA / Montefiore University Hospital of Albert Einstein College of Medicine. Department of Internal Medicine. Bronx, New York, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | UCLA David Geffen School of Medicine. Department of Medicine. Division of Infectious Diseases. Program in Global Health. Los Angeles, CA, USA / Montefiore University Hospital of Albert Einstein College of Medicine. Department of Internal Medicine. Bronx, New York, USA. | |
| Subject | High-Risk HPV | en_US |
| Subject | HPV Vaccine | en_US |
| Subject | Epidemiology | en_US |
| e-ISSN | 1878-3511 | |
