| Author | Côrtes, Fernanda H. | |
| Author | Passaes, Caroline P. B. | |
| Author | Bello, Gonzalo | |
| Author | Teixeira, Sylvia L. M. | |
| Author | Vorsatz, Carla | |
| Author | Babic, Dunja | |
| Author | Sharkey, Mark | |
| Author | Grinsztejn, Beatriz | |
| Author | Veloso, Valdiléa G. | |
| Author | Stenveson, Mario | |
| Author | Morgado, Mariza G. | |
| Access date | 2016-04-05T13:31:20Z | |
| Available date | 2016-04-05T13:31:20Z | |
| Document date | 2015 | |
| Citation | CÔRTES, Fernanda H. et al. HIV controllers with different viral load cut-off levels have distinct virologic and immunologic profiles. Journal of Acquired Immune Deficiency Syndromes, v. 68, n. 4, p. 377–385, Apr. 2015. | pt_BR |
| ISSN | 1525-4135 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13528 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | open access | |
| Title | HIV controllers with different viral load cut-off levels have distinct virologic and immunologic profiles | pt_BR |
| Type | Article | |
| DOI | 10.1097/QAI.0000000000000500 | |
| Abstract | Background—The mechanisms behind natural control of HIV replication are still unclear, and
several studies pointed that elite controllers are a heterogeneous group.
Methods—We performed analyses of virologic, genetic and immunologic parameters of HIV-1
controllers groups: 1) Elite Controllers (EC; VL <80 copies/mL); 2) Ebbing Elite Controllers
(EEC; transient viremia/blips); and Viremic Controllers (VC; detectable viremia <5,000 copies/
mL). Untreated non-controllers (NC), patients under suppressive HAART and HIV-1 negative
individuals were analyzed as controls.
Results—Total and integrated HIV-1 DNA for EC were significantly lower than for NC and
HAART groups. 2-LTR circles were detected in EEC (3/5) and VC (6/7) but not in EC. While EC
and EEC maintain normal T cell counts over time, some VC displayed negative CD4+ T cells
slopes. VC and EEC showed a higher percentage of activated CD8+ T cells and microbial
translocation than HIV-1 negative controls. EC displayed a weaker Gag/Nef IFN-γ T cell response
and a significantly lower proportion of anti-HIV IgG antibodies than EEC, VC and NC groups.
Conclusion—Transient/persistent low level viremia in HIV controllers may have an impact on
immunologic and virologic profiles. Classify HIV controllers patients taking into account their virologic profile may decrease the heterogeneity of HIV controllers cohorts, which may help to
clarify the mechanisms associated to the elite control of HIV. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Miami. Miller School of Medicine. Department of Medicine. Miami, FL, USA. | pt_BR |
| Affilliation | University of Miami. Miller School of Medicine. Department of Medicine. Miami, FL, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Miami. Miller School of Medicine. Department of Medicine. Miami, FL, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Elite controllers | pt_BR |
| Subject | Viral load blips | pt_BR |
| Subject | Ongoing replication | pt_BR |
| Subject | Immune activation | pt_BR |
| Subject | Immune response | pt_BR |
| Subject | Microbial translocation | |
| DeCS | HIV-1 | pt_BR |
| DeCS | Carga viral | pt_BR |
| DeCS | Replicon | pt_BR |
| e-ISSN | 1944-7884 | |
