| Author | Nicol, Alcina F. | |
| Author | Andrade, Cecília V. de | |
| Author | Russomano, Fabio B. | |
| Author | Rodrigues, Luana S. L. | |
| Author | Oliveira, Nathalia S. | |
| Author | Provance Jr., David William | |
| Author | Nuovo, Gerard J. | |
| Access date | 2016-04-05T14:15:46Z | |
| Available date | 2016-04-05T14:15:46Z | |
| Document date | 2015 | |
| Citation | NICOL, Alcina F. et al. HPV vaccines: their pathology-based discovery, benefits, and adverse effects. Annals of Diagnostic Pathology, v.19, n.6, p.418-422, Dec. 2015. | pt_BR |
| ISSN | 1092-9134 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13530 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Efeitos adversos | pt_BR |
| Title | HPV vaccines: their pathology-based discovery, benefits, and adverse effects | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.anndiagpath.2015.07.008 | |
| Abstract | The discovery of the human papillomavirus (HPV) vaccine illustrates the power of in situ–based pathologic analysis in better understanding and curing diseases. The 2 available HPV vaccines have markedly reduced the incidence of cervical intraepithelial neoplasias, genital warts, and cervical cancer throughout the world. Concerns about HPV vaccine safety have led some physicians, health care officials, and parents to refuse providing the recommended vaccination to the target population. The aims of the study were to discuss the discovery of HPV vaccine and review scientific data related to measurable outcomes from the use of HPV vaccines. The strong type-specific immunity against HPV in humans has been known for more than 25 years. Multiple studies confirm the positive risk benefit of HPV vaccination with minimal documented adverse effects. The most common adverse effect, injection site pain, occurred in about 10% of girls and was less than the rate reported for other vaccines. Use of HPV vaccine should be expanded into more diverse populations, mainly in low-resource settings. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Oeste do Pará. Instituto de Saúde Coletiva. PA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde (CDTS)/(INCT-IDPN). Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ohio State University Comprehensive Cancer Center. Columbus, OH, USA. | pt_BR |
| Subject | Human papillomavirus | pt_BR |
| Subject | HPV vaccine | pt_BR |
| Subject | Cervical cancer | pt_BR |
| Subject | Vaccination | pt_BR |
| Subject | Adverse events | pt_BR |
| DeCS | Papillomavirus Humano | pt_BR |
| DeCS | Vacinação | pt_BR |
| DeCS | HPV | pt_BR |
| DeCS | Câncer cervical | pt_BR |
| e-ISSN | 1532-8198 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
