Author | Adibi, Jennifer J. | |
Author | Marques Júnior, Ernesto Torres de Azevedo | |
Author | Cartus, Abigail | |
Author | Beigi, Richard H. | |
Access date | 2016-04-08T12:50:07Z | |
Available date | 2016-04-08T12:50:07Z | |
Document date | 2016 | |
Citation | ADIBI, Jennifer J.; MARQUES JUNIOR, Ernesto Torres de Azevedo; CARTUS, Abigail; BEIGI, Richard H. Teratogenic effects of the Zika virus and the role of the placenta. The Lancet, New York, p. 2-4, 4 Mar. 2016. Disponível em: <http://thelancet.com/pdfs/journals/lancet/PIIS0140-6736(16)00650-4.pdf>. Acesso em: 04 abr. 2016. | pt_BR |
ISSN | 0140-6736 | |
URI | https://www.arca.fiocruz.br/handle/icict/13657 | |
Description | Artigo liberado em acesso aberto como parte do acordo para tornar público todos os dados produzidos sobre o vírus zika - Compartilhamento de dados em emergências de saúde pública - http://www.wellcome.ac.uk/News/Media-office/Press-releases/2016/WTP060169.htm | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika vírus | pt_BR |
Subject in Portuguese | Microcefalia | pt_BR |
Subject in Portuguese | Epidemia | pt_BR |
Subject in Portuguese | Zika | pt_BR |
Title | Teratogenic effects of the Zika virus and the role of the placenta | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/S0140-6736(16)00650-4 | |
Abstract | The mechanism by which the Zika virus can cause fetal microcephaly is not known. Reports indicate that Zika is able to evade the normal immunoprotective responses of the placenta. Microcephaly has genetic causes, some associated
with maternal exposures including radiation, tobacco smoke, alcohol, and viruses. Two hypotheses regarding the role
of the placenta are possible: one is that the placenta directly conveys the Zika virus to the early embryo or fetus.
Alternatively, the placenta itself might be mounting a response to the exposure; this response might be contributing
to or causing the brain defect. This distinction is crucial to the diagnosis of fetuses at risk and the design of therapeutic strategies to prevent Zika-induced teratogenesis. | pt_BR |
Affilliation | Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh. Pittsburgh, PA, USA / Department of Obstetrics and Gynecology and Reproductive Sciences. University of Pittsburgh. Pittsburgh, PA, USA. | pt_BR |
Affilliation | Center for Vaccine Research. University of Pittsburgh, Pittsburgh, PA, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Affilliation | Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Sciences Center. Houston, Texas, USA. | pt_BR |
Affilliation | Department of Obstetrics and Gynecology and Reproductive Sciences. University of Pittsburgh. Pittsburgh, PA, USA. | pt_BR |
Subject | Zika Virus | pt_BR |
Subject | Microcephaly | pt_BR |
DeCS | Perigos Teratogênicos | pt_BR |
DeCS | Zika virus | pt_BR |
DeCS | Epidemic | pt_BR |