| Author | Miranda-Filho, Demócrito de Barros | |
| Author | Martelli, Celina Maria Turchi | |
| Author | Ximenes, Ricardo Arraes de Alencar | |
| Author | Araújo, Thalia Velho Barreto | |
| Author | Rocha, Maria Angela Wanderley | |
| Author | Ramos, Regina Coeli Ferreira | |
| Author | Dhalia, Rafael | |
| Author | França, Rafael Freitas de Oliveira | |
| Author | Marques Júnior, Ernesto Torres de Azevedo | |
| Author | Rodrigues, Laura Cunha | |
| Access date | 2016-04-08T14:22:07Z | |
| Available date | 2016-04-09T07:30:07Z | |
| Document date | 2016 | |
| Citation | MIRANDA-FILHO, Demócrito de Barros et al. Initial Description of the Presumed Congenital Zika Syndrome. American Journal of Public Health, Washington, DC, v. 106, n. 4, p. 598-600, Apr. 2016. | pt_BR |
| ISSN | 0090-0036 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13659 | |
| Language | eng | pt_BR |
| Publisher | American Public Health Association | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Zika vírus | pt_BR |
| Subject in Portuguese | Síndrome Zika | pt_BR |
| Subject in Portuguese | Epidemia | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Initial description of the presumed congenital Zika syndrome | pt_BR |
| Type | Article | |
| DOI | 10.2105/AJPH.2016.303115 | |
| Abstract | OBJECTIVES: To provide an initial description of the congenital syndrome presumably associated with infection by Zika virus compared with other syndromes including congenital infections of established etiologies. METHODS:
We provide an overview of a published case series of 35 cases, a clinical series of 104 cases, and published and unpublished reports of clinical and laboratory findings describing cases diagnosed since the beginning of the epidemic of microcephaly in Brazil. RESULTS:
About 60% to 70% of mothers report rash during pregnancy; mainly in the first trimester. Principal features are microcephaly, facial disproportionality, cutis girata, hypertonia/spasticity, hyperreflexia, and irritability; abnormal neuroimages include calcifications, ventriculomegaly, and lissencephaly. Hearing and visual abnormalities may be present. CONCLUSIONS:
Preliminary data suggest that severe congenital abnormalities are linked to Zika virus infection. Cases have severe abnormalities, and although sharing many characteristics with congenital abnormalities associated with other viral infections, abnormalities presumably linked to the Zika virus may have distinguishing characteristics. These severe neurologic abnormalities may result in marked mental retardation and motor disabilities for many surviving offspring.
POLICY IMPLICATIONS: Affected nations need to prepare to provide complex and costly multidisciplinary care that children diagnosed with this new congenital syndrome will require. | pt_BR |
| Affilliation | University of Pernambuco, Recife, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | University of Pernambuco, Recife, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco, Recife, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco, Recife, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco, Recife, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhaẽs. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhaẽs. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhaẽs. Recife, PE, Brasil. | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine, London, UK. | pt_BR |
| Subject | Zika Syndrome | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Epidemic | pt_BR |
| DeCS | Zika virus | pt_BR |
| DeCS | Epidemia | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
