| Autor | Vaz, Sara Nunes | |
| Autor | Giovanetti, Marta | |
| Autor | Rego, Filipe Ferreira de Almeida | |
| Autor | Oliveira, Tulio de | |
| Autor | Danaviah, Siva | |
| Autor | Gonçalves, Maria Luiza Freire | |
| Autor | Alcantara, Luiz Carlos Júnior | |
| Autor | Brites, Carlos | |
| Data de acesso | 2016-04-12T19:09:05Z | |
| Data de disponibilização | 2016-04-12T19:09:05Z | |
| Data do publicação | 2015 | |
| Citação | VAZ, S. N. et al. Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children. AIDS Research Human Retroviruses, v. 31, n. 10, p. 1046-1051, 2015. | pt_BR |
| ISSN | 1931-8405 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13738 | |
| Idioma | eng | pt_BR |
| Editor | Mary Ann Liebert | pt_BR |
| Direito Autoral | open access | pt_BR |
| Palavras-chave | HIV-1 | pt_BR |
| Palavras-chave | Virus | pt_BR |
| Palavras-chave | Transmissão | pt_BR |
| Palavras-chave | Infecção | pt_BR |
| Palavras-chave | Mutações | pt_BR |
| Palavras-chave | Feminino | pt_BR |
| Palavras-chave | Crianças | pt_BR |
| Título | Molecular Characterization of the Human Immunodeficiency Virus Type 1 in Women and Their Vertically Infected Children | pt_BR |
| Tipo do documento | Article | pt_BR |
| DOI | 10.1089/aid.2015.0166 | |
| Resumo em Inglês | Approximately 35 million people worldwide are infected with human immunodeficiency virus (HIV) around 3.2 million of whom are children under 15 years. Mother-to-child-transmission (MTCT) of HIV-1 accounts for 90% of all infections in children. Despite great advances in the prevention of MTCT in Brazil, children are still becoming infected. Samples from 19 HIV-1-infected families were collected. DNA was extracted and fragments from gag, pol, and env were amplified and sequenced directly. Phylogenetic reconstruction was performed. Drug resistance analyses were performed in pol and env sequences. We found 82.1% of subtype B and 17.9% of BF recombinants. A prevalence of 43.9% drug resistance-associated mutations in pol sequences was identified. Of the drug-naive children 33.3% presented at least one mutation related to protease inhibitor/nucleoside reverse transcriptase inhibitor/nonnucleoside reverse transcriptase inhibitor (PI/NRTI/NNRTI) resistance. The prevalence of transmitted drug resistance mutations was 4.9%. On env we found a low prevalence of HR1 (4.9%) and HR2 (14.6%) mutations | pt_BR |
| Afiliação | Universidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil / National Institute of Health. Department of Infectious, Parasitic and Immunomediated Diseases. Rome, Italy | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil | pt_BR |
| Afiliação | University of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa | pt_BR |
| Afiliação | University of KwaZulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa | pt_BR |
| Afiliação | Specialized Center in Diagnosis. Care and Research. Salvador, BA, Brasil | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, Ba, Brasil | pt_BR |
| Afiliação | Universidade Federal da Bahia. Laboratório de Retrovirologia. Salvador, BA, Brasil | pt_BR |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
