Author | Ichihara, Maria Yury Travassos | |
Author | Rodrigues, Laura C | |
Author | Santos, Carlos Antonio de Souza Teles | |
Author | Teixeiraa, Maria da Glória Lima Cruz | |
Author | Barreto, Maurício Lima | |
Access date | 2016-04-13T18:51:09Z | |
Available date | 2016-04-13T18:51:09Z | |
Document date | 2015 | |
Citation | ICHIHARA, M. Y. T. et al. Risk factors for hospital admission of Brazilian children with non-rotavirus diarrhoea: a case control-study. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 109, n. 7, p. 454-461, 2015. | pt_BR |
ISSN | 0035-9203 | |
URI | https://www.arca.fiocruz.br/handle/icict/13753 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Title | Risk factors for hospital admission of Brazilian children with non-rotavirus diarrhoea: a case control-study | pt_BR |
Type | Article | pt_BR |
Abstract | Background: Rotavirus has been the leading cause of severe cases of acute diarrhoea (AD) among children worldwide,
however, in the same areas, a large reduction in AD related to rotavirus has been observed after the introduction
of the rotavirus vaccine. In Brazil, where there is a high rotavirus vaccine coverage, AD caused by
pathogens other than rotavirus is still a frequent cause of outpatient visits and hospitalizations among children
under 5 years.
Methods: A hospital-based case-control study enrolled children aged 4 to 24 months admitted to 10 hospitals
from all five Brazilian Regions. Cases (n¼1178) were children admitted with diarrhoea who tested negative for
rotavirus in a stool sample. Controls (n¼2515) were children admitted without diarrhoea, frequency matched to
cases by sex and age group.We estimated odds ratios using logistic regression, in a hierarchical approach according
to a previously defined conceptual framework. Population-attributable fractions (PAF) were estimated for
each variable, each block and for all significant variables in the latter model adjusted.
Results: The factors studied accounted for 41% of the non-rotavirus AD hospital admissions and the main risk
factors included lack of adequate excreta disposal (PAF¼12%), untreated drinking water (PAF¼11%) and a history
of previous hospitalization due to AD (PAF¼21%). Low socio-economic conditions, no public water supply,
crowding and low weight-for-age made smaller contributions.
Conclusions: These findings further our knowledge of risk factors associated with severe AD in the post-rotavirus
vaccination era. We recommend further increase in coverage of basic sanitation, improvements in water quality
and further expansion of primary healthcare coverage to reduce the occurrence of non-rotavirus severe diarrhoea
and subsequent hospitalization of Brazilian children. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto da Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | London School of Hygiene & Tropical Medicine. London, United Kingdom | pt_BR |
Affilliation | State University of Feira de Santana. Feira de Santana, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto da Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto da Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Child hospitalization | pt_BR |
Subject | Diarrhoea | pt_BR |
Subject | Non-rotavirus diarrhea | pt_BR |
Subject | Risk factors for diarrhea | pt_BR |
DeCS | Diarreia | pt_BR |
DeCS | Hospitalização | pt_BR |
DeCS | Brasil/epidemiologia | pt_BR |
DeCS | Estudos de Casos e Controles | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Pré-escolar | pt_BR |
DeCS | Diarreia/epidemiologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Hospitalização/estatística & dados numéricos | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Lactente | pt_BR |
DeCS | Modelos Logísticos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Razão de Chances | pt_BR |
DeCS | Fatores de Risco | pt_BR |
DeCS | Saneamento/normas | pt_BR |