| Author | Driguez, Patrick | |
| Author | Li, Yuesheng | |
| Author | Jangola, Soraya Torres Gaze | |
| Author | Pearson, Mark S. | |
| Author | Nakajima, Rie | |
| Author | Trieu, Angela | |
| Author | Doolan, Denise L. | |
| Author | Felgner, Philip L. | |
| Author | Hou, Xunya | |
| Author | Cardoso, Fernanda C. | |
| Author | Jasinskas, Algis | |
| Author | Gobert, Geoffrey N. | |
| Author | Loukas, Alex | |
| Author | McManus, Donald P. | |
| Access date | 2016-04-14T16:03:23Z | |
| Available date | 2016-04-14T16:03:23Z | |
| Document date | 2016 | |
| Citation | DRIGUEZ, Patrick et al. Antibody signatures reflect different disease pathologies in schistosomiasis japonica. J Infect Dis., vol. 213, n. 1, p. 122-130, 2016. | pt_BR |
| ISSN | 0022-1899 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13775 | |
| Language | eng | pt_BR |
| Publisher | University of Chicago Press | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Antibody signatures reflect different disease pathologies in schistosomiasis japonica | pt_BR |
| Type | Article | |
| DOI | 10.1093/infdis/jiv356 | |
| Abstract | Infection with Schistosoma japonicum causes high levels of pathology that is predominantly determined by the cellular and humoral response of the host. However, the specific antibody response that arises during the development of disease is largely undescribed in Asian schistosomiasis-endemic populations. A schistosome protein microarray was used to compare the antibody profiles of subjects with acute infection, with early or advanced disease associated with severe pathology, with chronic infection, and subjects exposed but stool negative for S. japonicum eggs to the antibody profiles of nonexposed controls. Twenty-five immunodominant antigens were identified, including vaccine candidates, tetraspanin-related proteins, transporter molecules, and unannotated proteins. Additionally, individuals with severe pathology had a limited specific antibody response, suggesting that individuals with mild disease may use a broad and strong antibody response, particularly against surface-exposed proteins, to control pathology and/or infection. Our study has identified specific antigens that can discriminate between S. japonicum-exposed groups with different pathologies and may also allow the host to control disease pathology and provide resistance to parasite infection. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Brisbane. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Brisbane/Hunan Institute of Parasitic Diseases. Yueyang, China. | pt_BR |
| Affilliation | James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Queensland Tropical Health Alliance Laboratory. Cairns/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Queensland Tropical Health Alliance Laboratory. Cairns | pt_BR |
| Affilliation | University of California.Irvine, CA, USA. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Brisbane. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Brisbane. | pt_BR |
| Affilliation | University of California.Irvine, CA, USA. | pt_BR |
| Affilliation | Hunan Institute of Parasitic Diseases.Yueyang, China. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute/University of Queensland. Brisbane Institute for Molecular Biosciences. St. Lucia, Australia. | pt_BR |
| Affilliation | University of California.Irvine, CA, USA. | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Brisbane. | pt_BR |
| Affilliation | James Cook University. Australian Institute of Tropical Health and Medicine. Centre for Biodiscovery and Molecular Development of Therapeutics. Queensland Tropical Health Alliance Laboratory. Cairns | pt_BR |
| Affilliation | QIMR Berghofer Medical Research Institute. Brisbane. | pt_BR |
| Subject | Schistosoma japonicum | pt_BR |
| Subject | antibody | pt_BR |
| Subject | human disease | pt_BR |
| Subject | immunology | pt_BR |
| Subject | protein microarray | pt_BR |
| Subject | schistosomiasis | pt_BR |
