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AutorSavino, Wilson
AutorCruz, Daniella Arêas Mendes da
AutorGolbert, Daiane Cristina Ferreira
AutorRiederer, Ingo
AutorAlmeida, Vinicius Cotta de
Data de acesso2016-04-14T16:20:34Z
Data de disponibilização2016-04-14T16:20:34Z
Data do publicação2015
CitaçãoSAVINO, Wilson; et al. Laminin-Mediated Interactions in Thymocyte Migration and Development. Frontiers in Immunology, v.6, Article 579, 13p, Nov. 2015.pt_BR
ISSN1664-3224
URIhttps://www.arca.fiocruz.br/handle/icict/13776
Idiomaengpt_BR
EditorFrontiers Mediapt_BR
Direito Autoralopen access
TítuloLaminin-Mediated interactions in Thymocyte Migration and Developmentpt_BR
Tipo do documentoArticle
DOI10.3389/fimmu.2015.00579
Resumo em InglêsIntrathymic T-cell differentiation is a key process for the development and maintenance of cell-mediated immunity, and occurs concomitantly to highly regulated migratory events. We have proposed a multivectorial model for describing intrathymic thymocyte migration. One of the individual vectors comprises interactions mediated by laminins (LMs), a heterotrimeric protein family of the extracellular matrix. Several LMs are expressed in the thymus, being produced by microenvironmental cells, particularly thymic epithelial cells (TECs). Also, thymocytes and epithelial cells express integrin-type LM receptors. Functionally, it has been reported that the dy/dy mutant mouse (lacking the LM isoform 211) exhibits defective thymocyte differentiation. Several data show haptotactic effects of LMs upon thymocytes, as well as their adhesion on TECs; both effects being prevented by anti-LM or anti-LM receptor antibodies. Interestingly, LM synergizes with chemokines to enhance thymocyte migration, whereas classe-3 semaphorins and B ephrins, which exhibit chemorepulsive effects in the thymus, downregulate LM-mediated migratory responses of thymocytes. More recently, we showed that knocking down the ITGA6 gene (which encodes the α6 integrin chain of LM receptors) in human TECs modulates a large number of cell migration-related genes and results in changes of adhesion pattern of thymocytes onto the thymic epithelium. Overall, LM-mediated interactions can be placed at the cross-road of the multivectorial process of thymocyte migration, with a direct influence per se, as well as by modulating other molecular interactions associated with the intrathymic-trafficking events.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras-chave em inglêsThymuspt_BR
Palavras-chave em inglêsT-cell developmentpt_BR
Palavras-chave em inglêsThymic epithelial cellspt_BR
Palavras-chave em inglêsExtracellular matrixpt_BR
Palavras-chave em inglêsLaminin isoformspt_BR
Palavras-chave em inglêsIntegrinspt_BR
Palavras-chave em inglêsChemokinespt_BR
DeCSTimopt_BR
DeCSCélulas Epiteliaispt_BR
DeCSMatriz Extracelularpt_BR
DeCSLamininapt_BR
DeCSIsoformaspt_BR
DeCSIntegrinaspt_BR
DeCSQuimiocinaspt_BR


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