| Author | Passero, Luiz Felipe Domingues | |
| Author | Assis, Rafael Ramiro de | |
| Author | Silva, Thays Nicolli Fragoso da | |
| Author | Nogueira, Paula Monalisa | |
| Author | Macedo, Diego Henrique Fagundes | |
| Author | Pessoa, Natália Lima | |
| Author | Campos, Marco Antônio Silva | |
| Author | Laurenti, Marcia Dalastra | |
| Author | Soares, Rodrigo Pedro Pinto | |
| Access date | 2016-04-14T17:12:13Z | |
| Available date | 2016-04-14T17:12:13Z | |
| Document date | 2015 | |
| Citation | PASSERO, Luiz Felipe Domingues et al. Differential modulation of macrophage response elicited by glycoinositolphospholipids and lipophosphoglycan from Leishmania (Viannia) shawi. Parasitol Int., vol. 64, n. 4, p. 32-35, 2015 | pt_BR |
| ISSN | 1383-5769 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13780 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Differential modulation of macrophage response elicited by glycoinositolphospholipids and lipophosphoglycan from Leishmania (Viannia) shawi | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.parint.2015.01.006 | |
| Abstract | In this work, some aspects of the glycobiology of Leishmattia shawl were examined, as it is a causative agent of cutaneous leishmaniasis in the New World. Additionally, the interaction of L. shawl's main glycoconjugates [lipophosphoglycan (LPG) and glycoinositolphospholipids (GIPLs)] with macrophages was evaluated in vitro. L. shawl LPG was devoid of side-chains in its repeat units, whereas monosaccharide analysis showed that GIPLs were suggestive of mannose-rich (type I or hybrid). In order to evaluate the biological roles of those molecules, BALB/c resident peritoneal macrophages were incubated with these glycoconjugates for 24 h, and the levels of nitric oxide (NO), tumor necrosis factor (TNF)-alpha, interleukin (IL)-12p70 and IL-10, were determined. In general, the GIPLs exhibited a greater proinflammatory role than the LPGs did. However, for the first time, the GIPLs from this species were able to trigger the production of IL-10, an anti-inflammatory cytokine. In conclusion, L shawl glycoconjugates were able to interact with the innate immune compartment. These data reinforce the role of parasite glycoconjugates during parasite and host cell interactions. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | Leishmania (Viannia) | pt_BR |
| Subject | shawi | pt_BR |
| Subject | lipophosphoglycan | pt_BR |
| Subject | Glycoinositolphospholipids Interaction | pt_BR |
