| Author | Aleluia, Milena Magalhães | |
| Author | Mello, Marco Antônio Gomes | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Rego, Filipe Ferreira de Almeida | |
| Author | Santos, Lucas Pereira de Souza | |
| Author | Castro Filho, Bernardo Galvão | |
| Author | Gonçalves, Marilda de Souza | |
| Author | Oliveira, Túlio de | |
| Author | Marin, Lauro Juliano | |
| Author | Sousa, Sandra Mara Bispo | |
| Author | Gadelha, Sandra Rocha | |
| Access date | 2016-04-19T17:36:19Z | |
| Available date | 2016-04-19T17:36:19Z | |
| Document date | 2015 | |
| Citation | ALELUIA, M. M. et al. The origin of HTLV-1 in southern Bahia by phylogenetic, mtDNA and β-globin analysis. Virology Reports, v. 5, p. 63–74, 2015. | pt_BR |
| ISSN | 2214-6695 | |
| URI | https://www.arca.fiocruz.br/handle/icict/13874 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | The origin of HTLV-1 in southern Bahia by phylogenetic, mtDNA and β-globin analysis | pt_BR |
| Type | Article | pt_BR |
| DOI | dx.doi.org/10.1016/j.virep.2015.05.002 | |
| Abstract | Different hypotheses have been elaborated to explain how the HTLV
spread throughout theworld. It has been proposed that the viruswas
introduced in Bahia, during the slave-trade period from the 16th
century to 19th century. However, there is no information about
the HTLV evolutionary history in southern Bahia. The phylogeny is
fundamental in order to clarify its introduction and dispersion. The
DNA of 29 samples was extracted, followed by nested-PCR assay
for the LTR and DNA sequencing. These sequences were analyzed
by phylogenic methods. The mtDNA ancestry markers and βA-globin
haplotypes were analyzed by PCR/RFLP. In relation to HTLV subtyping,
all samples were classified as cosmopolitan subtype and transcontinental
subgroup. Results suggest an ancient post-Columbian introduction of
HTLV-1a-A associatedwith the slave trade between the XVI and late XIX
centuries in southern Bahia. As regards the ethnicity of HTLV-infected
women, the haplotype characterization of β-globin gene and the
mtDNA ethnicity of HTLV-infected women, we have detected a major | pt_BR |
| Affilliation | Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil | pt_BR |
| Affilliation | Fundação Baiana para o Desenvolvimento das Ciências. Escola Baiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Trust-Africa Centre for Health and Population Studies and Southern African Treatment Research Network. South Africa | pt_BR |
| Affilliation | Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual do Sudoeste da Bahia. Vitória da Conquista, BA, Brasil | pt_BR |
| Affilliation | Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil | pt_BR |
| Subject | HTLV-1a-A | pt_BR |
| Subject | HTLV-1 in Brazil | pt_BR |
| Subject | Ancestry | pt_BR |
| Subject | Phylogeny | pt_BR |
| Subject | Viral spread | pt_BR |
