Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/14140
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Coleções
- IOC - Artigos de Periódicos [12363]
Metadata
Mostrar registro completo
PROFILE OF INTERFERON-GAMMA RESPONSE TO LATENCY-ASSOCIATED AND NOVEL IN VIVO EXPRESSED ANTIGENS IN A COHORT OF SUBJECTS RECENTLY EXPOSED TO MYCOBACTERIUM TUBERCULOSIS
Tuberculosis
LTBI
Interferon gamma
Immune response
Latency-associated antigens
10.1016/j.tube.2015.08.002
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Helio Fraga Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Helio Fraga Filho. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Helio Fraga Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Helio Fraga Filho. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Recently some latency-associated antigens (LAA) of Mycobacterium tuberculosis were described, as Rv2029c, Rv2031c, Rv2034, Rv2628 and Rv3353c. Of which, the Rv2034 and Rv3353c also demonstrated in vivo expression. Therefore evaluating the immune response to these antigens may help to understand their role in latent TB infection. In a 1-year longitudinal study, IFN-γ response by in vitro peripheral blood mononuclear cells stimulation with LAA was investigated in subjects recently exposed to TB, classified by IFN-γ release assay (IGRA) using RD1 antigens (ESAT-6:CFP-10) and tuberculin skin test (TST) response. Except for Rv3353c, all the LAA triggered higher mean IFN-γ response in IGRA-RD1+ groups (p < 0.05). Combining the IFN-γ-responders to Rv2029c, Rv2031c plus Rv2034 detected 90.3% (28/31) of IGRA-RD1+ and 66.7% (24/36) of TST+ contacts, while 95% (19/20) and 11% (2/17) were identified by classifying them according to a TST and IGRA-RD1 double-positive or double-negative response, respectively. In the follow-up, the TST convertors (negative to positive) also demonstrated an IFN-γ conversion to Rv2029c and Rv2031c, whereas the unique TB incident case was exclusively detected via IGRA-Rv2029c and TST before developing TB. A reversion rate to LAA (60%–100%) after prophylactic treatment was observed at TST+/IGRA-RD1+ group. Further studies into the performance of these antigens are thus warranted.
Palavras-chave em inglês
Mycobacterium tuberculosisTuberculosis
LTBI
Interferon gamma
Immune response
Latency-associated antigens
Editor
Elsevier
Referência
ARAUJO, Leonardo Silva de; et al. Profile of interferon-gamma response to latency-associated and novel in vivo expressed antigens in a cohort of subjects recently exposed to Mycobacterium tuberculosis. Tuberculosis, v.95, n.6, p.751-757, Dec. 2015.ISSN
1472-979210.1016/j.tube.2015.08.002
Compartilhar