| Author | Passos, Geraldo Aleixo | |
| Author | Cruz, Daniella Arêas Mendes da | |
| Author | Oliveira, Emma Hérida | |
| Access date | 2016-05-19T14:08:30Z | |
| Available date | 2016-05-19T14:08:30Z | |
| Document date | 2015 | |
| Citation | PASSOS, Geraldo Aleixo; CRUZ, Daniella Arêas Mendes da; OLIVEIRA, Emma Hérida. The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance. Frontiers in Immunology, v.6, Article 352, 7p, July 2015. | pt_BR |
| ISSN | 1664-3224 | |
| URI | https://www.arca.fiocruz.br/handle/icict/14392 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Title | The thymic orchestration involving Aire, miRNAs, and cell–cell interactions during the induction of central tolerance | pt_BR |
| Type | Article | |
| DOI | 10.3389/fimmu.2015.00352 | |
| Abstract | Developing thymocytes interact sequentially with two distinct structures within the thymus:
the cortex and medulla. Surviving single-positive and double-positive thymocytes
from the cortex migrate into the medulla, where they interact with medullary thymic
epithelial cells (mTECs). These cells ectopically express a vast set of peripheral tissue
antigens (PTAs), a property termed promiscuous gene expression that is associated with
the presentation of PTAs by mTECs to thymocytes. Thymocyte clones that have a high
affinity for PTAs are eliminated by apoptosis in a process termed negative selection,
which is essential for tolerance induction. The Aire gene is an important factor that
controls the expression of a large set of PTAs. In addition to PTAs, Aire also controls the
expression of miRNAs in mTECs. These miRNAs are important in the organization of the
thymic architecture and act as posttranscriptional controllers of PTAs. Herein, we discuss
recent discoveries and highlight open questions regarding the migration and interaction
of developing thymocytes with thymic stroma, the ectopic expression of PTAs by mTECs,
the association between Aire and miRNAs and its effects on central tolerance. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Genética. Grupo de Imunogenética Molecular. Ribeirão Preto, SP, Brasil / Universidade de São Paulo. Escola de Odontologia de Ribeirão Preto. Departamento de Morfologia, Fisiologia e Patologia Básica. Disciplinas de Genética e Biologia Molecular. Ribeirão Preto, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Departamento de Genética. Grupo de Imunogenética Molecular. Ribeirão Preto, SP, Brasil. | pt_BR |
| Subject | AIRE | pt_BR |
| Subject | mIRNA | pt_BR |
| Subject | MTEC | pt_BR |
| Subject | Thymus gland | pt_BR |
| Subject | Thymocites | pt_BR |
| Subject | Cell adhesion | pt_BR |
| Subject | Promiscuous gene expression | pt_BR |
| Subject | Central tolerance | pt_BR |
| DeCS | MicroRNAs | pt_BR |
| DeCS | Timo | pt_BR |
| DeCS | Adesão Celular | pt_BR |
| DeCS | Tolerância Central | pt_BR |
