| Author | Simões, Rachel Siqueira de Queiroz | |
| Author | Barth, Ortrud Monika | |
| Access date | 2016-06-02T13:05:57Z | pt_BR |
| Access date | 2016-06-03T12:34:19Z | |
| Available date | 2016-06-02T13:05:57Z | pt_BR |
| Available date | 2016-06-03T12:34:19Z | |
| Document date | 2015 | pt_BR |
| Citation | SIMÕES, Rachel Siqueira de Queiroz; BARTH, Ortrud Monika. Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets. International Journal of Biomedical Research, v.6, n.10, p.763-768, 2015. | pt_BR |
| ISSN | 2455-0566 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14438 | |
| Language | eng | pt_BR |
| Publisher | Scholar Science Journals | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Papilomavírus | pt_BR |
| Subject in Portuguese | Vectores virais e não virais | pt_BR |
| Subject in Portuguese | Cromossomos | pt_BR |
| Subject in Portuguese | Terapia de genes | pt_BR |
| Title | Papillomavirus: Viral vectors in the gene therapy and new therapeutic targets | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.7439/ijbr | pt_BR |
| Abstract | Epitheliotropic and mucosotropic Papillomaviruses (PVs) constitute the Papillomaviridae family.
There are 26 genera comprising levels of inter species genetic similarities by nucleotide sequence analysis of the
L1 viral region, the generally most conserved region among papillomaviruses. There is an increasing consensus
that the ideal vector for gene therapy should be completely based on chromosomal elements and behave as an
independent functional unit after integration. The present paper is a short review about epidemiology of HPV
infection, vaccines anti-HPV and tumors associated with HPV and gene therapy including biological vectors,
stem cells, viral and non-viral vectors and chromosome-based vectors. Furthermore, new therapeutic targets and
vectors applied in gene therapy of other viruses are some of the examples that have been successfully modified
by recombinant DNA techniques. New biotechnologies in molecular biology have been applied in
papillomavirus research and are still being investigated for the application in the gene therapy. RNA-sequencing
(RNA-seq) for analysis of the transcriptome, multiply-primed rolling circle amplification (RCA) used to identify
novel human papillomaviruses (HPV) and new DNA sequencing method based on real-time phyrophosphate are
examples as new techniques. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Papillomavirus | pt_BR |
| Subject | Viral and non-viral vector | pt_BR |
| Subject | Chromosomes | pt_BR |
| Subject | Gene therapy | pt_BR |
| e-ISSN | 0976-9633 | pt_BR |
