| Author | Leon, Luciane Almeida Amado | |
| Author | Marchevsky, Renato Sergio | |
| Author | Gaspar, Ana Maria Coimbra | |
| Author | Garcia, Rita de Cassia Nasser Cubel | |
| Author | Almeida, Adilson José de | |
| Author | Pelajo-Machado, Marcelo | |
| Author | Castro, Tatiana Xavier de | |
| Author | Nascimento, Jussara Pereira do | |
| Author | Brown, Kevin E. | |
| Author | Pinto, Marcelo Alves | |
| Access date | 2016-06-23T18:37:02Z | pt_BR |
| Access date | 2016-07-07T11:58:42Z | |
| Available date | 2016-06-23T18:37:02Z | pt_BR |
| Available date | 2016-07-07T11:58:42Z | |
| Document date | 2016 | |
| Citation | LEON, Luciane Almeida Amado; et al. Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A virus: no evidence of the co-infection as a cause of acute liver failure. Mem Inst Oswaldo Cruz, v.111, n.4, p. 258-266, Apr. 2016. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14639 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Co-infecção | pt_BR |
| Subject in Portuguese | Insuficiência hepática aguda | pt_BR |
| Subject in Portuguese | Macacos cinomolgos | pt_BR |
| Subject in Portuguese | Parvovirus B19 Humano | pt_BR |
| Subject in Portuguese | Hepatite A | pt_BR |
| Title | Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A virus: no evidence of the co-infection as a cause of acute liver failure | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-02760160013 | pt_BR |
| Abstract | This study was conducted to analyse the course and the outcome of the liver disease in the co-infected animals in
order to evaluate a possible synergic effect of human parvovirus B19 (B19V) and hepatitis A virus (HAV) co-infection.
Nine adult cynomolgus monkeys were inoculated with serum obtained from a fatal case of B19V infection and/or a faecal
suspension of acute HAV. The presence of specific antibodies to HAV and B19V, liver enzyme levels, viraemia, haematological
changes, and necroinflammatory liver lesions were used for monitoring the infections. Seroconversion was
confirmed in all infected groups. A similar pattern of B19V infection to human disease was observed, which was characterised
by high and persistent viraemia in association with reticulocytopenia and mild to moderate anaemia during
the period of investigation (59 days). Additionally, the intranuclear inclusion bodies were observed in pro-erythroblast
cell from an infected cynomolgus and B19V Ag in hepatocytes. The erythroid hypoplasia and decrease in lymphocyte
counts were more evident in the co-infected group. The present results demonstrated, for the first time, the susceptibility
of cynomolgus to B19V infection, but it did not show a worsening of liver histopathology in the co-infected group. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Controle de Neurovirulência. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Escola de Medicina e Cirurgia. Hospital Universitário Gaffrée e Guinle. Unidade de Hematologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Health Protection Agency. Virus Reference Department. London, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Parvovirus B19 | pt_BR |
| Subject | Hepatitis A | pt_BR |
| Subject | Acute liver failure | pt_BR |
| Subject | Co-infection | pt_BR |
| Subject | Cynomolgus monkeys | pt_BR |
| DeCS | Hepatite A | pt_BR |
| e-ISSN | 1678-8080 | pt_BR |
