| Author | Barbosa, Lúcio Macedo | pt_BR |
| Author | Reis, Eliana Almeida Gomes | pt_BR |
| Author | Santos, Cláudio R. A. dos | pt_BR |
| Author | Costa, Jackson Mauricio Lopes | pt_BR |
| Author | Carmo, Theomira Mauadie de Azevedo | pt_BR |
| Author | Aminu, Peace T | pt_BR |
| Author | Pitanga, Thassila Nogueira | pt_BR |
| Author | Terashima, Rafael Ponce | pt_BR |
| Author | Blank, Walter A | pt_BR |
| Author | Silva, Luciano Kalabric | pt_BR |
| Author | Reis, Mitermayer Galvão dos | pt_BR |
| Author | Blanton, Ronald Edward | pt_BR |
| Access date | 2016-06-30T14:32:42Z | pt_BR |
| Access date | 2016-07-07T11:39:48Z | |
| Available date | 2016-06-30T14:32:42Z | pt_BR |
| Available date | 2016-07-07T11:39:48Z | |
| Document date | 2016 | |
| Citation | BARBOSA, L. M. et al. Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission. International Journal for Parasitology, v. 46, p. 343–350, 2016. | pt_BR |
| ISSN | 0020-7519 | pt_BR |
| ISSN | dx.doi.org/10.1016/j.ijpara.2016.01.007 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14706 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission | pt_BR |
| Type | Article | pt_BR |
| Abstract | Repeated treatments with praziquantel reduce schistosomiasis prevalence and morbidity, but transmission
persists and populations often recover within a few years. To identify factors associated with persistence,
we surveyed and treated all identified Schistosoma mansoni infections in two rural Brazilian
communities (Jenipapo and Volta do Rio) in 2009, 2012 and 2013. Eggs were collected from all infected
individuals and genotyped with 11 microsatellite markers to evaluate parasite differentiation and diversity.
After successive rounds of community-wide treatment, prevalence decreased from 45% to 24% then
16%. Intensity of infection decreased by 57% over this period, and the number of eggs transmitted to the
environment decreased by 92%. During all time periods the majority of eggs were excreted by those
>15 years of age. The incidence was 23% in 2012 and 15% in 2013, consistent with a decrease in transmission.
There was little immigration or gene flow over a distance of 6 km. On reinfection, infrapopulations
were moderately differentiated indicating that pretreatment multilocus genotypes were not fully reacquired.
The effective population size responded to census population decline more rapidly than differentiation.
Reinfection was concentrated in the downstream portion of Jenipapo, consistent with the
observed increased human fecal contamination. At this scale and in this area S. mansoni infections exist
on a fragmented landscape with a highly focal pattern of transmission that may facilitate future
elimination. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Case Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USA | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Mercer University School of Medicine. Macon, USA | pt_BR |
| Affilliation | Case Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USA | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil | pt_BR |
| Affilliation | Case Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USA | pt_BR |
| Subject | Effective population size | pt_BR |
| Subject | Genetic differentiation | pt_BR |
| Subject | Extinction | pt_BR |
| Subject | Praziquantel | pt_BR |
| Subject | Reinfection | pt_BR |
| Subject | Spatial analysis | pt_BR |
| Subject | Brazil | pt_BR |
