| Author | Bessa, Theolis Costa Barbosa | pt_BR |
| Author | Arruda, Sérgio Marcos | pt_BR |
| Author | Fernandes, Bruno D | pt_BR |
| Author | Carvalho, Lucas Pedreira | pt_BR |
| Author | Cardoso, Silvia | pt_BR |
| Author | Cunha, Sérgio | pt_BR |
| Author | Barreto, Maurício Lima | pt_BR |
| Author | Pereira, Susan Martins | pt_BR |
| Author | Rodrigues, Laura C | pt_BR |
| Author | Barral Netto, Manoel | pt_BR |
| Access date | 2016-06-30T18:04:02Z | pt_BR |
| Access date | 2016-07-07T11:39:48Z | |
| Available date | 2016-06-30T18:04:02Z | pt_BR |
| Available date | 2016-07-07T11:39:48Z | |
| Document date | 2003 | |
| Citation | BARBOSA, T. et al. BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children. Vaccine, v. 21, p. 2152–2160, May 2003. | pt_BR |
| ISSN | 0264-410X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14711 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | BCG (Bacille of Calmette–Guérin) revaccination leads to improved in vitro IFN- response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children | pt_BR |
| Type | Article | pt_BR |
| Abstract | Tuberculin skin test (TST) response and cytokine production in finger stab-derived whole blood cultures from 136 BCG scar-positive
school-age children were evaluated before and after BCG revaccination. Fifty-four percent of the children increased in vitro production
of IFN- after revaccination, and this increase was highly significant for previously unresponsive children (P < 0.0001). No correlation
was found between TST response and cytokine production. Our data suggest that the in vitro IFN- response to mycobacterial antigens
can be boosted by BCG revaccination and may contribute to the search of correlates of protection to be used for the evaluation of new
mycobacterial vaccines. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
| Affilliation | London School of Hygiene and Tropical Medicine. London, UK | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
| Subject | Immunological markers | pt_BR |
| Subject | Tuberculosis: immune response; | pt_BR |
| Subject | IFN | pt_BR |
| Subject | TNF | pt_BR |
| Subject | IL-10 | pt_BR |
