Author | Bomfim, Maria da Glória | pt_BR |
Author | Andrade, Bruno de Bezerril | pt_BR |
Author | Santos, Silvane | pt_BR |
Author | Andrade, Jorge Clarêncio de Souza | pt_BR |
Author | Barral Netto, Manoel | pt_BR |
Author | Barral, Aldina Maria Prado | pt_BR |
Access date | 2016-07-06T14:31:03Z | pt_BR |
Access date | 2016-07-07T19:04:20Z | |
Available date | 2016-07-06T14:31:03Z | pt_BR |
Available date | 2016-07-07T19:04:20Z | |
Document date | 2007 | pt_BR |
Citation | BOMFIM, M. G. et al. Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease. American Journal of Tropical Medicine and Hygiene, v. 77, n. 5, p. 854–859, 2007. | pt_BR |
ISSN | 0002-9637 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/14794 | |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | pt_BR |
Title | Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease | pt_BR |
Type | Article | pt_BR |
Abstract | Lymphadenopathy is an early clinical sign in cutaneous leishmaniasis (CL), caused by Viannia parasites,
and may help to understand the initial host response to these species of Leishmania. We report on characteristics of cells
obtained from lymph nodes from cutaneous leishmaniasis patients with lymphadenopathy without ulceration (early
phase, N 21) or lymphadenopathy and ulceration (late phase, N 29). Early-phase patients exhibited a higher
proportion of neutrophils, eosinophils, and CD8+ T cells. Conversely, CD19+ B lymphocytes and plasma cells were more
frequently observed in late-phase patients. The signal for IL-10 was significantly higher in late-phase patients; signals for
IFN- or IL-4 were similar in both groups. These data reinforce observations of an initial mixed Th1–Th2 profile as well
as the early role of the CD8 T cell in cutaneous leishmaniasis. Additionally, there is a chronologic relationship between
ulcer development and B-cell increase. IL-10 also increases at a late stage and may be important in limiting tissue
damage. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto do Milênio. Instituto de Investigação em Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto do Milênio. Instituto de Investigação em Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Leishmania | pt_BR |
Subject | IL10 protein, | pt_BR |
Subject | Interleukin-10 | pt_BR |
Subject | Plasma Cells | pt_BR |
Subject | Cutaneous Leishmaniasis | pt_BR |
Subject | Lymphadenopathy | pt_BR |
Subject | Animals | pt_BR |