| Author | Adachi, Kristina | |
| Author | Klausner, Jeffrey D. | |
| Author | Bristow, Claire C. | |
| Author | Xu, Jiahong | |
| Author | Ank, Bonnie | |
| Author | Morgado, Mariza G. | |
| Author | Watts, D. Heather | |
| Author | Weir, Fred | |
| Author | Persing, David | |
| Author | Mofenson, Lynne M. | |
| Author | Veloso, Valdiléa G. | |
| Author | Pilotto, José Henrique | |
| Author | João, Esau | |
| Author | Nielsen-Saines, Karin | |
| Access date | 2016-07-07T11:36:52Z | pt_BR |
| Access date | 2016-07-08T18:49:08Z | |
| Available date | 2016-07-07T11:36:52Z | pt_BR |
| Available date | 2016-07-08T18:49:08Z | |
| Document date | 2015 | |
| Citation | ADACHI, Kristina; et al. Chlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission. Sexually Transmitted Diseases, v.42, n.10, p.554-565, Oct. 2015. | pt_BR |
| ISSN | 0148-5717 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14805 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Clamídia | pt_BR |
| Subject in Portuguese | Gonorréia | pt_BR |
| Subject in Portuguese | Grávidas infectadas com o VIH | pt_BR |
| Subject in Portuguese | Transmissão infantil do HIV | pt_BR |
| Title | Chlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission | pt_BR |
| Type | Article | |
| DOI | 10.1097/OLQ.0000000000000340 | pt_BR |
| Abstract | Background: Sexually transmitted infections (STIs) such as Chlamydia
trachomatis (CT) and Neisseria gonorrhoeae (NG) can lead to adverse
pregnancy and neonatal outcomes. The prevalence of STIs and its association
with HIV mother-to-child transmission (MTCT) were evaluated in a
substudy analysis from a randomized, multicenter clinical trial.
Methodology: Urine samples from HIV-infected pregnant women collected
at the time of labor and delivery were tested using polymerase chain
reaction testing for the detection of CT and NG (Xpert CT/NG; Cepheid,
Sunnyvale, CA). Infant HIV infection was determined by HIV DNA polymerase
chain reaction at 3 months.
Results: Of the 1373 urine specimens, 249 (18.1%) were positive for CT
and 63 (4.6%) for NG; 35 (2.5%) had both CT and NG detected. Among
117 cases of HIV MTCT (8.5% transmission), the lowest transmission rate
occurred among infants born to CT- and NG-uninfected mothers (8.1%) as
compared with those infected with only CT (10.7%) and both CT and NG
(14.3%; P = 0.04). Infants born to CT-infected mothers had almost a 1.5-
fold increased risk for HIV acquisition (odds ratio, 1.47; 95% confidence
interval, 0.9–2.3; P = 0.09).
Conclusions: This cohort of HIV-infected pregnant women is at high risk
for infection with CT and NG. Analysis suggests that STIs may predispose
to an increased HIV MTCT risk in this high-risk cohort of HIVinfected
women. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA.USA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA.USA. | pt_BR |
| Affilliation | Fielding School of Public Health. UCLA. Los Angeles, CA.USA. | pt_BR |
| Affilliation | Westat. Rockville, MD, USA. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA.USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | US Department of State. Office of the Global AIDS Coordinator. Washington, DC, USA. | pt_BR |
| Affilliation | Cepheid. Sunnyvale, CA, USA. | pt_BR |
| Affilliation | Cepheid. Sunnyvale, CA, USA. | pt_BR |
| Affilliation | National Institutes of Health. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Bethesda, MD, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen UCLA School of Medicine. Los Angeles, CA.USA. | pt_BR |
| Subject | Chlamydia | pt_BR |
| Subject | Gonorrhea | pt_BR |
| Subject | HIV-Infected Pregnant Women | pt_BR |
| Subject | Infant HIV Transmission | pt_BR |
| e-ISSN | 1537-4521 | pt_BR |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
